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Journal articles
Meiotic Genes Are Enriched in Regions of Reduced Archaic Ancestry
Abstract : About 1–6% of the genetic ancestry of modern humans today originates from admixture with archaic humans. It has recently been shown that autosomal genomic regions with a reduced proportion of Neanderthal and Denisovan ancestries (NA and DA) are significantly enriched in genes that are more expressed in testis than in other tissues. To determine whether a cellular segregation pattern would exist, we combined maps of archaic introgression with a cross-analysis of three transcriptomic datasets deciphering the transcriptional landscape of human gonadal cell types. We reveal that the regions deficient in both NA and DA contain a significant enrichment of genes transcribed in meiotic germ cells. The interbreeding of anatomically modern humans with archaic humans may have introduced archaic-derived alleles that contributed to genetic incompatibilities affecting meiosis that were subsequently purged by natural selection.
Cited literature [30 references]
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01578587
Contributor : Laurent Jonchère Connect in order to contact the contributor
Submitted on : Monday, September 25, 2017 - 10:15:42 AM
Last modification on : Wednesday, October 20, 2021 - 3:19:22 AM
Long-term archiving on: : Tuesday, December 26, 2017 - 12:42:55 PM
Contributor : Laurent Jonchère Connect in order to contact the contributor
Submitted on : Monday, September 25, 2017 - 10:15:42 AM
Last modification on : Wednesday, October 20, 2021 - 3:19:22 AM
Long-term archiving on: : Tuesday, December 26, 2017 - 12:42:55 PM
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Jégou et al - Meiotic Genes A...
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