Meiotic Genes Are Enriched in Regions of Reduced Archaic Ancestry - Archive ouverte HAL Access content directly
Journal Articles Molecular Biology and Evolution Year : 2017

Meiotic Genes Are Enriched in Regions of Reduced Archaic Ancestry

Abstract

About 1–6% of the genetic ancestry of modern humans today originates from admixture with archaic humans. It has recently been shown that autosomal genomic regions with a reduced proportion of Neanderthal and Denisovan ancestries (NA and DA) are significantly enriched in genes that are more expressed in testis than in other tissues. To determine whether a cellular segregation pattern would exist, we combined maps of archaic introgression with a cross-analysis of three transcriptomic datasets deciphering the transcriptional landscape of human gonadal cell types. We reveal that the regions deficient in both NA and DA contain a significant enrichment of genes transcribed in meiotic germ cells. The interbreeding of anatomically modern humans with archaic humans may have introduced archaic-derived alleles that contributed to genetic incompatibilities affecting meiosis that were subsequently purged by natural selection.
Fichier principal
Vignette du fichier
Jégou et al - Meiotic Genes Are Enriched.pdf (194.52 Ko) Télécharger le fichier
Origin : Files produced by the author(s)
Loading...

Dates and versions

hal-01578587 , version 1 (25-09-2017)

Identifiers

Cite

B. Jégou, S. Sankararaman, Antoine D. Rolland, D. Reich, F. Chalmel. Meiotic Genes Are Enriched in Regions of Reduced Archaic Ancestry. Molecular Biology and Evolution, 2017, 34 (8), pp.1974-1980. ⟨10.1093/molbev/msx141⟩. ⟨hal-01578587⟩
197 View
220 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More