Skip to Main content Skip to Navigation
Journal articles

Meiotic Genes Are Enriched in Regions of Reduced Archaic Ancestry

Abstract : About 1–6% of the genetic ancestry of modern humans today originates from admixture with archaic humans. It has recently been shown that autosomal genomic regions with a reduced proportion of Neanderthal and Denisovan ancestries (NA and DA) are significantly enriched in genes that are more expressed in testis than in other tissues. To determine whether a cellular segregation pattern would exist, we combined maps of archaic introgression with a cross-analysis of three transcriptomic datasets deciphering the transcriptional landscape of human gonadal cell types. We reveal that the regions deficient in both NA and DA contain a significant enrichment of genes transcribed in meiotic germ cells. The interbreeding of anatomically modern humans with archaic humans may have introduced archaic-derived alleles that contributed to genetic incompatibilities affecting meiosis that were subsequently purged by natural selection.
Document type :
Journal articles
Complete list of metadata

Cited literature [30 references]  Display  Hide  Download
Contributor : Laurent Jonchère Connect in order to contact the contributor
Submitted on : Monday, September 25, 2017 - 10:15:42 AM
Last modification on : Wednesday, October 20, 2021 - 3:19:22 AM
Long-term archiving on: : Tuesday, December 26, 2017 - 12:42:55 PM


Jégou et al - Meiotic Genes A...
Files produced by the author(s)



B. Jégou, S. Sankararaman, Antoine D. Rolland, D. Reich, F. Chalmel. Meiotic Genes Are Enriched in Regions of Reduced Archaic Ancestry. Molecular Biology and Evolution, Oxford University Press (OUP), 2017, 34 (8), pp.1974-1980. ⟨10.1093/molbev/msx141⟩. ⟨hal-01578587⟩



Record views


Files downloads