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Plan delivery quality assurance for CyberKnife: Statistical process control analysis of 350 film-based patient-specific QAs

Abstract : Purpose: Robotic radiosurgery requires plan delivery quality assurance (DQA) but there has never been a published comprehensive analysis of a patient-specific DQA process in a clinic. We proposed to evaluate 350 consecutive film-based patient-specific DQAs using statistical process control. We evaluated the performance of the process to propose achievable tolerance criteria for DQA validation and we sought to identify suboptimal DQA using control charts. Methods and material: DQAs were performed on a CyberKnife-M6 using Gafchromic-EBT3 films. The signal-to-dose conversion was performed using a multichannel-correction and a scanning protocol that combined measurement and calibration in a single scan. The DQA analysis comprised a gamma-index analysis at 3%/1.5 mm and a separate evaluation of spatial and dosimetric accuracy of the plan delivery. Each parameter was plotted on a control chart and control limits were calculated. A capability index (Cpm) was calculated to evaluate the ability of the process to produce results within specifications. Results: The analysis of capability showed that a gamma pass rate of 85% at 3%/1.5 mm was highly achievable as acceptance criteria for DQA validation using a film-based protocol (Cpm > 1.33). 3.4% of DQA were outside a control limit of 88% for gamma pass-rate. The analysis of the out-of-control DQA helped identify a dosimetric error in our institute for a specific treatment type. Conclusion: We have defined initial tolerance criteria for DQA validations. We have shown that the implementation of a film-based patient-specific DQA protocol with the use of control charts is an effective method to improve patient treatment safety on CyberKnife. (C) 2017 Associazione Italiana di Fisica Medica. Published by Elsevier Ltd. All rights reserved.
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https://hal-univ-rennes1.archives-ouvertes.fr/hal-01579370
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Submitted on : Thursday, August 31, 2017 - 9:35:54 AM
Last modification on : Wednesday, May 16, 2018 - 11:23:42 AM

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J. Bellec, N. Delaby, F. Jouyaux, M. Perdrieux, J. Bouvier, et al.. Plan delivery quality assurance for CyberKnife: Statistical process control analysis of 350 film-based patient-specific QAs. Physica Medica, Elsevier, 2017, 39, pp.50--58. ⟨10.1016/j.ejmp.2017.06.016⟩. ⟨hal-01579370⟩

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