Classification of Patients With GH Disorders May Vary According to the IGF-I Assay - Université de Rennes Accéder directement au contenu
Article Dans Une Revue Journal of Clinical Endocrinology and Metabolism Année : 2017

Classification of Patients With GH Disorders May Vary According to the IGF-I Assay

Résumé

Context: Insulinlike growth factor I (IGF-I) measurement is essential for the diagnosis and management of growth hormone (GH) disorders. However, patient classification may vary substantially according to the assay technique. Objective: We compared individual patient data and classifications obtained with six different IGF-I assay kits in a group of patients with various GH disorders. Design: In this cross-sectional study, we measured IGF-I with six immunoassays in 102 patients with active or treated acromegaly or GH deficiency. IGF-I normative data previously established for the same six assay kits were used to classify the patients (high, low, or normal IGF-I levels), using both raw data and standard deviation scores (SDSs). Pairwise concordance between assays was assessed with Bland-Altman plots and with the percentage of observed agreement and the weighted κ coefficient for categorized IGF-I SDS. Results: We observed marked variability both across each individual's IGF-I raw data and across IGF-I SDS values obtained with each of the six immunoassays. Pairwise concordance between assay values, as assessed with the weighted κ coefficient, ranged from 0.50 (moderate) to 0.81 (excellent). Conclusion: Even when using normative data obtained in the same large population of healthy subjects and when using calculated IGF-I SDSs, agreement among IGF-I assay methods is only moderate to good. Differences in assay performance must be taken into account when evaluating and monitoring patients with GH disorders. This argues for the use of the same IGF-I assay for a given patient throughout follow-up.
Fichier principal
Vignette du fichier
Classification of patients with GH disorders_accepted.pdf (1.05 Mo) Télécharger le fichier
Classification of patients with GH disorders_supplementary material.pdf (71.25 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)
Loading...

Dates et versions

hal-01579404 , version 1 (10-11-2017)

Identifiants

Citer

Maria Mavromati, Emmanuelle Kuhn, Hélène Agostini, Sylvie Brailly-Tabard, Catherine Massart, et al.. Classification of Patients With GH Disorders May Vary According to the IGF-I Assay. Journal of Clinical Endocrinology and Metabolism, 2017, 102 (8), pp.2844-2852. ⟨10.1210/jc.2017-00202⟩. ⟨hal-01579404⟩
506 Consultations
279 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More