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F. G. Nationale-de-la-recherche-et-de-la-technologie, F. Kan-31528711, F. Kan-1504813, N. , and F. G0e04, Research in the Vandenabeele group is supported by Belgian grants (Interuniversity Attraction Poles Ghent University grants (MRP, GROUP-ID consortium, BOFGOA2014000702), grants from the Foundation against Cancer (F94), and grants from VIB. AF was supported by a PhD fellowship from the " Région Bretagne " . MF was supported by a PhD fellowship from the Government of Pakistan (Higher Education Commission PV is senior full professor at Ghent University and holds a Methusalem grant For immunohistochemistry analysis and animal house facilities, Acknowledgements This work was supported by the INSERM Flemish grants (Research Foundation Flanders: FWO G.0875.11, FWO G.0973.11, FWO G.0A45.12 N Methusalem grant Christelle Manuel and Aurélien Jan for technical assistance and William Taylor for the English proofreading

M. F. , C. P. , V. G. , and J. L. , Experiments were conducted by A Data were analysed and interpreted by, Author Contributions Studies

M. S. and J. L. , S. have equally contributed to this work as co-senior authors