S. Lin, K. Hoffmann, and P. Schemmer, Treatment of Hepatocellular Carcinoma: A Systematic Review, Liver Cancer, vol.1, issue.3-4, pp.144-158, 2012.
DOI : 10.1159/000343828

A. Jernal, F. Bray, and M. Center, Global cancer statistics, CA Cancer J. Clin, vol.61, issue.2, pp.69-90, 2011.

X. Zhang, H. Ng, H. Lu, and A. , Drug delivery system targeting advanced hepatocellular carcinoma: Current and future, Nanomedicine: Nanotechnology, Biology and Medicine, vol.12, issue.4, pp.853-869, 2016.
DOI : 10.1016/j.nano.2015.12.381

S. Jin, H. Jin, and S. Hong, Targeted Delivery System of Nanobiomaterials in Anticancer Therapy: From Cells to Clinics, BioMed Research International, vol.102, issue.4, 2014.
DOI : 10.1038/nnano.2011.166

H. Ringsdorf, Structure and properties of pharmacologically active polymers, Journal of Polymer Science: Polymer Symposia, vol.9, issue.1
DOI : 10.1016/0014-2964(73)90058-3

Y. Mastumura and H. Maeda, A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and antitumor agent smancs, Cancer Research, vol.46, issue.12, pp.6387-6392, 1986.

J. Fang, H. Nakamura, and H. Maeda, The EPR effect: Unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect, Advanced Drug Delivery Reviews, vol.63, issue.3
DOI : 10.1016/j.addr.2010.04.009

L. Wang, B. Tian, and J. Zhang, Coordinated pH/redox dual-sensitive and hepatoma-targeted multifunctional polymeric micelle system for stimuli-triggered doxorubicin release: Synthesis, characterization and in vitro evaluation, International Journal of Pharmaceutics, vol.501, issue.1-2, pp.221-235, 2016.
DOI : 10.1016/j.ijpharm.2016.02.002

E. Craparo, M. Licciardi, and A. Connigliaro, Hepatocyte-targeted fluorescent nanoparticles based on polyaspartamide for potential theranostic applications Galactosylated pullulan-curcumin conjugate micelles for site-specific anticancer activity to hepatocarcinoma cells, Polymer. Colloids and Surfaces B: Biointerfaces, vol.7010, issue.133, pp.257-270, 2015.

X. Qi, Y. Rui, and Y. Fan, Galactosylated chitosan-grafted multiwall carbon nanotubes for pH-dependent sustained release and hepatic tumor-targeted delivery of doxorubicin in vivo Development of biodegradable nanoparticles for liver-specific ribavirin delivery Endocytosis and degradation mediated by the asialoglycoprotein receptor in isolated rat hepatocytes, Colloids and Surfaces B: Biointerfaces. J. Pharm. Sci. J. Biol. Chem, vol.133121314, issue.257, pp.314-322, 1982.

S. Dunn, A. Brindley, and S. Davis, Polystyrene-poly(ethylene glycol

R. Gref, Y. Minamitake, and M. Peracchia, Biodegradable long-circulating polymer nanospheres Amphipatic poly(ethylene glycols) effectively prolong the circulation time of liposomes, Science. FEBS Lett, vol.26317, issue.268, pp.1600-1603, 1990.

J. Park, S. Lee, and J. Kim, Polymeric nanomedicine for cancer therapy, Progress in Polymer Science, vol.33, issue.1
DOI : 10.1016/j.progpolymsci.2007.09.003

E. Holler, Poly(malic acid) from Natural Sources, Handbook of Engineering Polymeric Materials: Marcel Dekker, pp.93-103, 1997.

S. Cammas, R. I. Langlois, and V. , Poly(?-malic acid): obtaining of high molecular weights by improvement of the synthesis route Natural and synthetic poly(malic acid)-based derivates: A family of versatile biopolymers for the design of drug nanocarriers, Polymer. J. Drug Targ, vol.3722, issue.227, pp.4215-4220, 1996.

P. Gripon, S. Rumin, and S. Urban, Nonlinear partial differential equations and applications: Infection of a human hepatoma cell line by hepatitis B virus, Proceedings of the National Academy of Sciences, vol.20, issue.16, pp.15655-15660, 2002.
DOI : 10.1093/emboj/20.16.4443

V. Laurent, A. Fraix, and T. Montier, Highly efficient gene transfer into hepatocyte-like HepaRG cells: New means for drug metabolism and toxicity studies, Biotechnology Journal, vol.17, issue.3, pp.314-320, 2010.
DOI : 10.1089/hum.2006.17.882

URL : https://hal.archives-ouvertes.fr/hal-00552337

V. Laurent, D. Glaise, and T. Nübel, Highly Efficient SiRNA and Gene Transfer into Hepatocyte-Like HepaRG Cells and Primary Human Hepatocytes: New Means for Drug Metabolism and Toxicity Studies, Methods Mol. Biol, vol.987, pp.295-314, 2013.
DOI : 10.1007/978-1-62703-321-3_25

URL : https://hal.archives-ouvertes.fr/hal-00865763

M. Vert and R. Lenz, Preparation and properties of poly-?-malic acid: a functional polyester of potential biomedical importance [27] Lown WJ et al. Anthracycline and anthraquinone anticancer agents: Current status and recentdevelopments, ACS Polym. Preprint. Pharmacol.Ther, vol.20, issue.60, pp.608-611, 1979.

R. Patil, J. Portilla-arias, and H. Ding, Cellular Delivery of Doxorubicin via pH-Controlled Hydrazone Linkage Using Multifunctional Nano Vehicle Based on Poly(??-L-Malic Acid), International Journal of Molecular Sciences, vol.65, issue.12, pp.11681-11693, 2012.
DOI : 10.1016/0022-1759(83)90303-4

J. Soutif and J. Brosse, Chemical modification of polymers, Reactive Polymers, vol.13, issue.1-2
DOI : 10.1016/0923-1137(90)90037-5

H. Ding, S. Inoue, and A. Ljubimov, Inhibition of brain tumor growth by intravenous poly(??-L-malic acid) nanobioconjugate with pH-dependent drug release, Proceedings of the National Academy of Sciences, vol.8, issue.1-2
DOI : 10.1186/1471-2342-8-16

R. Patil, A. Ljubimov, and P. Gangalum, MRI Virtual Biopsy and Treatment of Brain Metastatic Tumors with Targeted Nanobioconjugates Nanoclinic in the Brain A review of the formation and classification of amphiphilic block copolymer nanoparticulate structures: micelles, nanospheres, nanocapsules and polymersomes. Eur, ACS Nano. J. Pharm. Biopharm, vol.65, pp.259-269, 2007.

D. Kang, M. Kim, and S. Kim, Size characterization of drug-loaded polymeric core/shell nanoparticles using asymmetrical flow field-flow fractionation, Analytical and Bioanalytical Chemistry, vol.54, issue.9
DOI : 10.1007/s00216-008-1984-1

E. Zablackis and J. Poli, Doi: 10.1007/s00216-008-1984-1 Characterization of ?-carrageenan solution behavior by field-flow fractionation and multi angle light scattering, Chem. Food Hydrocolloids, vol.390, issue.22, pp.2183-2188, 2008.