Skip to Main content Skip to Navigation
Journal articles

Regulatory myeloid cells: an underexplored continent in B-cell lymphomas

Abstract : In lymphomas arising from the germinal center, prognostic factors are linked to the myeloid compartment. In particular, high circulating monocyte or myeloid-derived suppressor cell counts are associated with poor prognosis for patients with high-grade B-cell lymphomas. Macrophages with an M2 phenotype are enriched within lymphoma tumors. However, the M1/M2 nomenclature is now deprecated and the clinical impact of this phenotype remains controversial. Across cancer types, myeloid cells are primarily thought to function as immune suppressors during tumor initiation and maintenance, but the biological mechanisms behind the myeloid signatures are still poorly understood in germinal center B-cell lymphomas. Herein, we describe the role and clinical relevance of myeloid cells in B-cell lymphoma and propose innovative approaches to decipher this complex cellular compartment. Indeed, characterization of this heterogeneous cell ecosystem has been largely accomplished with "low-resolution" approaches like morphological evaluation and immunohistochemistry, where cells are characterized using a few proteins and qualitative metrics. High-resolution, quantitative approaches, such as mass cytometry, are valuable to better understand myeloid cell diversity, functions, and to identify potential targets for novel therapies.
Document type :
Journal articles
Complete list of metadatas

Cited literature [69 references]  Display  Hide  Download

https://hal-univ-rennes1.archives-ouvertes.fr/hal-01579827
Contributor : Laurent Jonchère <>
Submitted on : Thursday, August 31, 2017 - 4:42:20 PM
Last modification on : Saturday, February 15, 2020 - 7:16:05 PM
Long-term archiving on: : Friday, December 1, 2017 - 7:46:06 PM

File

2017_Roussel_FRR_CII_R2.pdf
Files produced by the author(s)

Identifiers

Citation

Mikael Roussel, Jonathan M. Irish, Cédric Menard, Faustine Lhomme, Karin Tarte, et al.. Regulatory myeloid cells: an underexplored continent in B-cell lymphomas. Cancer Immunology, Immunotherapy, Springer Verlag, 2017, 66 (8), pp.1103-1111. ⟨10.1007/s00262-017-2036-5⟩. ⟨hal-01579827⟩

Share

Metrics

Record views

223

Files downloads

344