Skip to Main content Skip to Navigation
Journal articles

Effect of acute millimeter wave exposure on dopamine metabolism of NGF-treated PC12 cells

Abstract : Several forthcoming wireless telecommunication systems will use electromagnetic frequencies at millimeter waves (MMWs), and technologies developed around the 60-GHz band will soon know a widespread distribution. Free nerve endings within the skin have been suggested to be the targets of MMW therapy which has been used in the former Soviet Union. So far, no studies have assessed the impact of MMW exposure on neuronal metabolism. Here, we investigated the effects of a 24-h MMW exposure at 60.4 GHz, with an incident power density (IPD) of 5 mW/cm2, on the dopaminergic turnover of NGF-treated PC12 cells. After MMW exposure, both intracellular and extracellular contents of dopamine (DA) and 3,4-dihydroxyphenylacetic acid (DOPAC) were studied using high performance liquid chromatography. Impact of exposure on the dopamine transporter (DAT) expression was also assessed by immunocytochemistry. We analyzed the dopamine turnover by assessing the ratio of DOPAC to DA, and measuring DOPAC accumulation in the medium. Neither dopamine turnover nor DAT protein expression level were impacted by MMW exposure. However, extracellular accumulation of DOPAC was found to be slightly increased, but not significantly. This result was related to the thermal effect, and overall, no evidence of non-thermal effects of MMW exposure were observed on dopamine metabolism. © 2017 The Author. Published by Oxford University Press on behalf of The Japan Radiation Research Society and Japanese Society for Radiation Oncology.
Document type :
Journal articles
Complete list of metadata

Cited literature [48 references]  Display  Hide  Download
Contributor : Laurent Jonchère <>
Submitted on : Wednesday, June 20, 2018 - 2:59:45 PM
Last modification on : Thursday, March 25, 2021 - 4:36:46 PM
Long-term archiving on: : Tuesday, September 25, 2018 - 9:20:36 AM


Haas - Effect of acute millime...
Publisher files allowed on an open archive


Distributed under a Creative Commons Attribution 4.0 International License



A.J. Haas, Y. Le Page, M. Zhadobov, R. Sauleau, Y.L. Dréan, et al.. Effect of acute millimeter wave exposure on dopamine metabolism of NGF-treated PC12 cells. Journal of Radiation Research, Oxford University Press (OUP), 2017, 58 (4), pp.439--445. ⟨10.1093/jrr/rrx004⟩. ⟨hal-01580502⟩



Record views


Files downloads