Skip to Main content Skip to Navigation
Journal articles

Endoplasmic reticulum stress signaling and chemotherapy resistance in solid cancers

Abstract : The unfolded protein response (UPR) is an adaptive cellular program used by eukaryotic cells to cope with protein misfolding stress. During tumor development, cancer cells are facing intrinsic (oncogene activation) and extrinsic (limiting nutrient or oxygen supply) challenges, with which they must cope to survive. Moreover, chemotherapy represents an additional extrinsic challenge that cancer cells are facing and to which they adapt in the case of resistance. As of today, resistance to chemotherapy and targeted therapies is one of the important issues that oncologists have to deal with for treating cancer patients. In this review, we first describe the key molecular mechanisms controlling the UPR and their implication in solid cancers. Then, we review the literature that connects cancer chemotherapy resistance mechanisms and activation of the UPR. Finally, we discuss the possible applications of targeting the UPR to bypass drug resistance.
Complete list of metadatas

Cited literature [152 references]  Display  Hide  Download

https://hal-univ-rennes1.archives-ouvertes.fr/hal-01586176
Contributor : Laurent Jonchère <>
Submitted on : Wednesday, June 20, 2018 - 4:32:08 PM
Last modification on : Wednesday, March 27, 2019 - 3:06:02 PM

File

Avril - Endoplasmic reticulum ...
Publisher files allowed on an open archive

Licence


Distributed under a Creative Commons Attribution 4.0 International License

Identifiers

Citation

T. Avril, E. Vauléon, E. Chevet. Endoplasmic reticulum stress signaling and chemotherapy resistance in solid cancers. Oncogenesis, Nature Publishing Group: Open Access Journals - Option C, 2017, 6 (8), pp.e373. ⟨10.1038/oncsis.2017.72⟩. ⟨hal-01586176⟩

Share

Metrics

Record views

166

Files downloads

135