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Managing Drug-Drug Interaction between Ombitasvir, Paritaprevir/Ritonavir, Dasabuvir, and Mycophenolate Mofetil

Abstract : No drug-drug interaction study has been conducted to date for the combination of ombitasvir, paritaprevir/ritonavir, dasabuvir (3D), and mycophenolic acid (MPA). We here report the case of a hepatitis C virus-infected patient treated with 3D and MPA for vasculitis. In light of the threat of drug-drug interaction, the concentration of MPA was measured before, during, and 15 days after the end of the 3D treatment. Similar values were found at all 3 time points, thus indicating that there is probably no need to adapt MPA dosage to 3D. Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved.
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https://hal-univ-rennes1.archives-ouvertes.fr/hal-01614699
Contributor : Laurent Jonchère <>
Submitted on : Wednesday, October 11, 2017 - 11:59:15 AM
Last modification on : Thursday, June 18, 2020 - 9:29:15 AM

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F. Lemaitre, Z. Ben Ali, C. Tron, C. Jezequel, C. Boglione-Kerrien, et al.. Managing Drug-Drug Interaction between Ombitasvir, Paritaprevir/Ritonavir, Dasabuvir, and Mycophenolate Mofetil. Therapeutic Drug Monitoring, Lippincott, Williams & Wilkins, 2017, 39 (4), pp.305-307. ⟨10.1097/FTD.0000000000000397⟩. ⟨hal-01614699⟩

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