The role of the capping bond effect on pyclen Y-nat(3+)/Y-90(3+) chelates: full control of the regiospecific N-functionalization makes the difference

Mariane Le Fur (1) , Maryline Beyler (1) , Eniko Molnar (2) , Olivier Fougere (3) , David Esteban-Gomez (4) , Gyula Tircso (2) , Carlos Platas-Iglesias (4) , Nicolas Lepareur (5) , Olivier Rousseaux (2) , Raphaël Tripier (1)

1 CEMCA - Chimie, Electrochimie Moléculaires et Chimie Analytique
2 University of Debrecen Egyetem [Debrecen]
3 Guerbet Group
4 Universidad de A Coruña
5 NuMeCan - Nutrition, Métabolismes et Cancer

Thanks to a smart regiospecific N-functionalization, a pyclen based ligand bearing one picolinate and two acetate arms organized in a dissymmetric manner was synthesized for Y3+ complexation, and compared to its symmetric analogue. The nature of the capping bonds around the metal coordination environment has a dramatic effect on the properties of the chelate, the Y-nat(3+) and Y-90(3+) dissymmetric derivatives presenting enhanced thermodynamic stability and kinetic inertness.

Domains: Life Sciences [q-bio]; Cancer; Life Sciences [q-bio]; Food and Nutrition; Life Sciences [q-bio]; Human health and pathology; Endocrinology and metabolism

Mariane Le Fur, Maryline Beyler, Eniko Molnar, Olivier Fougere, David Esteban-Gomez, et al.. The role of the capping bond effect on pyclen Y-nat(3+)/Y-90(3+) chelates: full control of the regiospecific N-functionalization makes the difference. Chemical Communications, 2017, 53 (69), pp.9534-9537. ⟨10.1039/c7cc05088g⟩. ⟨hal-01616222⟩