Skip to Main content Skip to Navigation
Journal articles

The interaction of iron and the genome: For better and for worse

Abstract : Iron, as an essential nutrient, and the DNA, as the carrier of genetic information which is physically compacted into chromosomes, are both needed for normal life and well-being. Therefore, it is not surprising that close interactions exist between iron and the genome. On the one hand, iron, especially when present in excess, may alter genome stability through oxidative stress, and may favor cell cycle abnormalities and the development of malignant diseases. The genome also receives a feedback signal from the systemic iron status, leading to promotion of expression of genes that regulate iron metabolism. Conversely, on the other hand, DNA mutations may cause genetic iron-related diseases such as hemochromatosis, archetype of iron-overload diseases, or refractory iron deficiency anemia (IRIDA). © 2017 Elsevier B.V.
Document type :
Journal articles
Complete list of metadatas

Cited literature [74 references]  Display  Hide  Download

https://hal-univ-rennes1.archives-ouvertes.fr/hal-01616421
Contributor : Xavier Chard-Hutchinson <>
Submitted on : Tuesday, October 24, 2017 - 3:56:01 PM
Last modification on : Thursday, February 27, 2020 - 4:40:50 PM
Long-term archiving on: : Thursday, January 25, 2018 - 1:55:41 PM

File

Troadec et al. - 2017 - The in...
Files produced by the author(s)

Identifiers

Citation

Marie-Bérengère Troadec, O. Loréal, P. Brissot. The interaction of iron and the genome: For better and for worse. Mutation Research - Reviews, Elsevier, 2017, 774, pp.25-32. ⟨10.1016/j.mrrev.2017.09.002⟩. ⟨hal-01616421⟩

Share

Metrics

Record views

408

Files downloads

426