!. G. Beatty, !. Hara, !. M. Chimeric, !. , !. et al., !Imaging!of!Genetically!Engineered!T!Cells!by!PET!using!Gold!Nanoparticle! 883! Complexed!to!Copper@64! 888! Biodegradable!Copolymer!for!Stimuli@Responsive!Sustained!Release!of!Doxorubicin.!ACS! 889! Omega!1,!108?117!Resistance!to!anti@CD19!Potent!antibody!therapeutics!by!design!A!novel!vaccine!adjuvant!for! 906! recombinant!flu!antigens!Targeted!delivery!of!anti@CD19!liposomal! 910! doxorubicin!in!B@cell!lymphoma:!A!comparison!of!whole!monoclonal!antibody,!Fab?! 911! fragments!and!single!chain!Fv!MRI!and!18F@ 913! FDG@PET/CT!in!a!rare!case!of!early!(precursor)!B@lymphoblastic!leukaemia!with!bone! 914! involvement!as!initial!manifestation, Efficacy!and!Toxicity!Management!of!19@ 920! 28z!CAR!T!Cell!Therapy!in!B!Cell!Acute!Lymphoblastic!Leukemia.!Sci.!Transl.!Med.!6, pp.30-39141, 2006.

!. M. Dong, !. Y. Tian, !. Pappas, !. D. Eyquem, !. J. Mansilla@soto et al., !Targeting!a!CAR!to!the!TRAC!locus! 927! with!CRISPR/Cas9!enhances!tumour!rejection.!Nature!543!The!Promise!of!Chimeric!Antigen!Receptor!T@Cell! 929! Therapy!|!Cancer!Network!Extracellular!matrix:!A!dynamic! 931! microenvironment!for!stem!cell!niche!Potent! 934! antitumor!activity!of!the!anti@CD19!auristatin!antibody!drug!conjugate!hBU12@vcMMAE! 935! against!rituximab@sensitive!and!@resistant!lymphomas.!Blood!113!Review:!Current!clinical!applications!of!chimeric! 937! antigen!receptor!(CAR)!modified!T!cells.!Cytotherapy!18!Going!viral:!chimeric!antigen!receptor!T@cell!therapy!for! 939! hematological!malignancies!Blinatumomab:!a!CD19!Plasmonic!photothermal!therapy!increases!the!tumor!mass!penetration!of! 944! HPMA!copolymers!Enhanced!permeability!and!retention!of!macromolecular!drugs!in! 946! solid!tumors:!a!royal!gate!for!targeted!anticancer!nanomedicines!CD19!as!an!attractive!target!for!antibody@based!therapy, Chimeric!Antigen!Receptor?Modified!T! 950! Cells!for!Acute!Lymphoid!Leukemia.! 951Design!of!Coltuximab!Ravtansine,!a!CD19@Targeting!Antibody? 959! Drug!Conjugate!(ADC)!for!the!Treatment!of!B@Cell!Malignancies:!Structure?Activity! 960! Relationships!and!Preclinical!Evaluation.! 961! Hudecek, pp.1598-924, 2006.

!. Nanoscale, !. Res, !. J. Lett-kochenderfer, !. M. Dudley, !. S. Feldman et al., !B@cell! 975! depletion!and!remissions!of!malignancy!along!with!cytokine@associated!toxicity!in!a! 976! clinical!trial!of!anti@CD19!chimeric@antigen@receptor?transduced!T!cells!A!hostel!for!the!hostile:!the!bone!marrow!niche!in! 979! hematologic!neoplasms.!Haematologica!100!Requirement!for! 981! CD44!in!homing!and!engraftment!of!BCR@ABL|[ndash]|expressing!leukemic!stem!cells!Differential!regulation!of!myeloid!leukemias!by! 985! the!bone!marrow!microenvironment!T!cells!expressing!CD19! 1000! chimeric!antigen!receptors!for!acute!lymphoblastic!leukaemia!in!children!and!young! 1001! adults:!a!phase!1!dose@escalation!trial.!The!Lancet!385!CD19,!from!bench!to! 1003! bedside, Molecular!Imaging!in!Tracking!Tumor@Specific!Cytotoxic!T! 1005! Lymphocytes!(CTLs).!Theranostics!4, pp.1376-13871175, 1998.

!. N. Riordan, !. Raimondi, !. C. The, !. Lysosomotropic, !. Agent et al., !The!bone!marrow!niche!for!haematopoietic! 1032! stem!cells.!Nature!505!CD19@antigen!specific!nanoscale!liposomal! 1035! formulation!of!a!SYK!P@site!inhibitor!causes!apoptotic!destruction!of!human!B@precursor! 1036! leukemia!cells!Musculoskeletal!Imaging!Findings!of!Hematologic!Malignancies.!Radiogr.! 1039! Rev!Chimeric!antigen!receptor!T@cell!therapy! 1041! for!solid!tumors! 1043! Detection!of!chronic!lymphocytic!leukemia!cell!surface!markers!using!surface!enhanced! 1044! Raman!scattering!gold!nanoparticles!CD19@targeted!CAR!T@cell!therapeutics! 1046! for!hematologic!malignancies:!interpreting!clinical!outcomes!to!date!Bromelain!Surface!Modification! 1050! Increases!the!Diffusion!of!New!Developments!in!Liposomal! 1053!A!computationally!designed!inhibitor!of! 1062! an!Epstein@Barr!viral!Bcl@2!protein!induces!apoptosis!in!infected!cells.!Cell!157,!1644!The!cancer@immunity!cycle!as! 1064! rational!design!for!synthetic!cancer!drugs:!Novel!DC!vaccines!and!CAR!T@cells.!Semin.! 1065! Cancer!Biol!The!Limitations!and!Promise!of! 1067! Immunotherapy!With!Chimeric!Antigen?Modified!T!Cells!|!Cancer!Network!Gold!nanoparticle@mediated!photothermal!therapy:! 1069! ! 43! applications!and!opportunities!for!multimodal!cancer!treatment!Improved!outcome!when!B@cell!lymphoma!is!treated! 1082! with!combinations!of!immunoliposomal!anticancer!drugs!targeted!to!both!the!CD19!and! 1083! CD20!epitopes!CD28!costimulation!improves!expansion!and! 1086! persistence!of!chimeric!antigen!receptor?modified!T!cells!in!lymphoma!patients!Cancer!nanomedicine:! 1102! progress,!challenges!and!opportunities!In!vivo!imaging!of!specialized!bone!marrow!endothelial! 1105! microdomains!for!tumour!engraftment.!Nature!435!Nanoscale!materials!for! 1107! hyperthermal!theranostics!Chimeric!antigen!receptor@modified!T!cells!derived!from! 1110! defined!CD8+!and!CD4+!subsets!confer!superior!antitumor!reactivity!in!vivo!CD19,!the!earliest!differentiation!antigen!of!the!B! 1113! cell!lineage,!bears!three!extracellular!immunoglobulin@like!domains!and!an!Epstein@Barr! 1114! virus@related!cytoplasmic!tail!Drug!discovery!and!therapeutic!delivery!for!the! 1116! treatment!of!B!and!T!cell!tumors!CD22?E12!as!a!molecular! 1133! target!for!RNAi!therapy!New!development!in!CAR@T!cell!therapy, Nanoscale!Artificial!Antigen! 1056! Presenting!Cells!for!T!Cell!Immunotherapy.!Nanomedicine!Nanotechnol.!Biol.!Med.!10,! 1057! 119.! 1058! Porter,Chimeric!Antigen! 1059! Receptor?Modified!T!Cells!in!Chronic!Lymphoid!Leukemia.! 1060! Procko,Targeting!CD19:!the!good,!the!badLipid!Encapsulation!of!Surface! 1137! Enhanced!Raman!Scattering!(sers)!Nanoparticles.! 1138! Wang!T!Cells! 1159! Expressing!CD19/CD20!Bispecific!Chimeric!Antigen!Receptors!Prevent!Antigen!Escape! 1160! by!Malignant!B!Cells.!Cancer!Immunol.!ResRare!Cell!Separation!and!Analysis!by!Magnetic! 1162! Sorting.!Anal.!Chem.!83, pp.97-103, 1051.