Rational and design of EuroCRT: an international observational study on multi-modality imaging and cardiac resynchronization therapy

Erwan Donal 1, 2, 3 Victoria Delgado Julien Magne 4, 5 Chiara Bucciarelli-Ducci Christophe Leclercq 2, 6, 1 Bernard Cosyns Marta Sitges 7 Thor Edvardsen 8 Elif Sade Ivan Stankovic Eustachio Agricola Maurizio Galderisi 9 Patrizio Lancellotti 10 Alfredo Hernandez 2 Sven Plein Denisa Muraru 11 Ehud Schwammenthal Gerhard Hindricks Bogdan A. Popescu Gilbert Habib 2
1 CIC-IT Rennes
2 LTSI - Laboratoire Traitement du Signal et de l'Image
3 CHU Pontchaillou [Rennes]
4 NET - Neuroépidémiologie Tropicale
5 Service de cardiologie [CHU Limoges]
6 Service de cardiologie et maladies vasculaires
7 Cardiology Department, Thorax Clinic Institute, Hospital Cliınic, Institut d'Investigacions Biomèdiques [Barcelona]
8 Oslo University Hospital
9 Università degli studi di Napoli Federico II
10 GIGA-Research - Groupe Interdisciplinaire de Génoprotéomique Appliquée
11 Universita degli Studi di Padova
Abstract : Aims: Assessment of left ventricular (LV) volumes and ejection fraction (LVEF) with cardiac imaging is important in the selection of patients for cardiac resynchronization therapy (CRT). Several observational studies have explored the role of imaging-derived LV dyssynchrony parameters to predict the response to CRT, but have yielded inconsistent results, precluding the inclusion of imaging-derived LV dyssynchrony parameters in current guidelines for selection of patients for CRT. Methods: The EuroCRT is a large European multicentre prospective observational study led by the European Association of Cardiovascular Imaging. We aim to explore if combing the value of cardiac magnetic resonance (CMR) and echocardiography could be beneficial for selecting heart failure patients for CRT in terms of improvement in long-term survival, clinical symptoms, LV function, and volumes. Speckle tracking echocardiography will be used to assess LV dyssynchrony and wasted cardiac work whereas myocardial scar will be assessed with late gadolinium contrast enhanced CMR. All data will be measured in core laboratories. The study will be conducted in European centres with known expertise in both CRT and multimodality cardiac imaging.
Keywords : Strain Cardiac magnetic resonance Cardiac resynchronization therapy echocardiography Observational study
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Journal articles
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https://hal-univ-rennes1.archives-ouvertes.fr/hal-01617888
Contributor : Laurent Jonchère <>
Submitted on : Tuesday, October 17, 2017 - 11:23:06 AM
Last modification on : Thursday, June 14, 2018 - 10:54:03 AM

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Erwan Donal, Victoria Delgado, Julien Magne, Chiara Bucciarelli-Ducci, Christophe Leclercq, et al.. Rational and design of EuroCRT: an international observational study on multi-modality imaging and cardiac resynchronization therapy. European Heart Journal Cardiovascular Imaging, 2017, 18, pp.1120-1127. ⟨10.1093/ehjci/jex021⟩. ⟨hal-01617888⟩

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