Skip to Main content Skip to Navigation
Journal articles

Ruthenium catalyzed β-C(sp(3))-H functionalization on the 'privileged' piperazine nucleus

Abstract : β-C(sp(3))-H functionalization on the 'privileged' piperazine nucleus has been disclosed using ruthenium catalysis. The ruthenium catalyzed synthesis of a variety of piperazine fused indoles from ortho-piperazinyl (hetero)aryl aldehydes is presented. This transformation takes place via the dehydrogenation of piperazine followed by an intramolecular nucleophilic addition of the transient enamine moiety onto the carbonyl group and aromatization cascade.
Document type :
Journal articles
Complete list of metadatas

https://hal-univ-rennes1.archives-ouvertes.fr/hal-01617950
Contributor : Laurent Jonchère <>
Submitted on : Friday, December 8, 2017 - 4:26:11 PM
Last modification on : Thursday, March 5, 2020 - 2:03:11 PM
Long-term archiving on: : Friday, March 9, 2018 - 12:16:03 PM

File

Murugesh - Ruthenium catalyzed...
Files produced by the author(s)

Identifiers

Citation

V. Murugesh, Christian Bruneau, Mathieu Achard, Apurba Ranjan Sahoo, Gangavaram V. M. Sharma, et al.. Ruthenium catalyzed β-C(sp(3))-H functionalization on the 'privileged' piperazine nucleus. Chemical Communications, Royal Society of Chemistry, 2017, 53 (75), pp.10448-10451. ⟨10.1039/C7CC05604D⟩. ⟨hal-01617950⟩

Share

Metrics

Record views

251

Files downloads

270