Ruthenium catalyzed β-C(sp(3))-H functionalization on the 'privileged' piperazine nucleus - Archive ouverte HAL Access content directly
Journal Articles Chemical Communications Year : 2017

Ruthenium catalyzed β-C(sp(3))-H functionalization on the 'privileged' piperazine nucleus

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Abstract

β-C(sp(3))-H functionalization on the 'privileged' piperazine nucleus has been disclosed using ruthenium catalysis. The ruthenium catalyzed synthesis of a variety of piperazine fused indoles from ortho-piperazinyl (hetero)aryl aldehydes is presented. This transformation takes place via the dehydrogenation of piperazine followed by an intramolecular nucleophilic addition of the transient enamine moiety onto the carbonyl group and aromatization cascade.
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Dates and versions

hal-01617950 , version 1 (08-12-2017)

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V. Murugesh, Christian Bruneau, Mathieu Achard, Apurba Ranjan Sahoo, Gangavaram V. M. Sharma, et al.. Ruthenium catalyzed β-C(sp(3))-H functionalization on the 'privileged' piperazine nucleus. Chemical Communications, 2017, 53 (75), pp.10448-10451. ⟨10.1039/C7CC05604D⟩. ⟨hal-01617950⟩
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