Design, Synthesis, and Reactivity of Multidentate Ligands with Rhenium(I) and Rhenium(V) Cores

Abstract : Synthetic pathways to a range of potentially N3O-tetradentate ligands designed to coordinate to rhenium cores, as well as their coordination behaviors towards different rhenium cores (oxidation states +I and +V) are investigated. Two functionalized N-{[1-(4-R)-1H-1,2,3-triazol-4-yl]methyl}-2-(pyridin-2-ylmethoxy)aniline derivatives L1H (R = methyl acetate) and L2H (R = 4-nitrophenyl) act exclusively as bidentate ligands and lead to the formation of mononuclear tricarbonylrhenium(I) complexes of the general formula [(LH)Re(CO)3Cl] with L = L1 or L2. Both complexes are characterized by 1H NMR and 13C NMR, FTIR spectroscopy, electrospray ionization mass spectrometry, and in the case of [(L2H)Re(CO)3Cl], single-crystal X-ray diffraction. The rhenium is coordinated by three carbonyl groups, a chlorine atom and two nitrogen atoms of a triazole group, and a nitrogen of the aniline ring of the ligand, respectively. A theoretical study shows complex [(L2H)Re(CO)3Cl] is the most stable structural isomer. In addition, the oxorhenium(V) complex [(L3)ReO] is isolated and fully characterized after the reaction of the ReV precursor [ReOCl3(PPh3)2] with L3H3 [methyl 2-(4-{[2-(2-hydroxyphenylamino)-2-oxoethylamino]methyl}-1H-1,2,3-triazol-1-yl)acetate]. Its corresponding 99mTc complex was achieved with a good radiochemical yield (andgt; 90 %). The convenient synthesis of this ligand, coupled with its high affinity for [ReO]3+ and [99mTcO]3+ cores, make it a promising chelator for biomedical applications. © 2017 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim
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European Journal of Inorganic Chemistry, Wiley-VCH Verlag, 2017, 2017 (33), pp.3908-3918. 〈10.1002/ejic.201700632〉
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Soumis le : jeudi 19 octobre 2017 - 14:26:38
Dernière modification le : mardi 11 septembre 2018 - 15:19:17

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J.-H. Wang, R. Eychenne, M. Wolff, S. Mallet-Ladeira, N. Lepareur, et al.. Design, Synthesis, and Reactivity of Multidentate Ligands with Rhenium(I) and Rhenium(V) Cores. European Journal of Inorganic Chemistry, Wiley-VCH Verlag, 2017, 2017 (33), pp.3908-3918. 〈10.1002/ejic.201700632〉. 〈hal-01619479〉

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