Two new cyclobutane dimers from Diospyros macrocarpa

Abstract : A biochemical and phytochemical study of Diospyros macrocarpa Hiern, an endemic plant of New Caledonia, was realized. Indeed, bark and leaf extracts were tested for their cytotoxic and antibiotic activities as well as for their radical scavenging properties. Methanol extracts showed promising radical scavenging activity with an IC50 value of 5.6 ± 0.9 μg/mL for the leaves and 8.1 ± 1.4 μg/mL for the barks. The ethyl acetate extract from the barks showed strong and selective activity against NCI-H727 cancer cell line with an IC50 value of 9.5 ± 0.6 μg/mL.. Two new cyclobutane dimers: macrocarpasin A (1) and B (2) (figure 1) together with six known compounds: yangonin (3), betulinic acid (4), α-amyrin (5), β-amyrin (6), loliolide (7) and oleanderolide (8) were isolated from leaf extracts. Their structures were established by 1D and 2D NMR along with HRMS analyses. Cytotoxic activities of isolated compounds were also evaluated. None of them showed interesting cytotoxicity against the seven tested cancer cell lines.
Type de document :
Article dans une revue
Natural Product Communications, 2017, 12 (8), pp.1277-1282
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Contributeur : Laurent Jonchère <>
Soumis le : jeudi 19 octobre 2017 - 15:41:27
Dernière modification le : lundi 26 mars 2018 - 14:49:30


  • HAL Id : hal-01619687, version 1



C. Thieury, R. Le Guével, G. Herbette, V. Monnier, N. Lebouvier, et al.. Two new cyclobutane dimers from Diospyros macrocarpa. Natural Product Communications, 2017, 12 (8), pp.1277-1282. 〈hal-01619687〉



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