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Preparation of imidazo[1,2-a]-N-heterocyclic derivatives with gem-difluorinated side chains

Abstract : Using an aerobic oxidative coupling, different new imidazo[1,2-]--heterocycles with -difluroroalkyl side chains have been prepared in fair yields by the reaction of -difluoroenones with aminopyridines, -pyrimidines and -pyridazines. Condensed heterocycles of this type play an important role as key core structures of various bioactive compounds. Further, starting with a chloroimidazopyridazine derivative, Pd-catalyzed coupling reactions as well as nucleophilic substitutions have been performed successfully in order to increase the molecular diversity.
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Layal Hariss, Kamal Bou Hadir, Mirvat El-Masri, Thierry Roisnel, René Grée, et al.. Preparation of imidazo[1,2-a]-N-heterocyclic derivatives with gem-difluorinated side chains. Beilstein Journal of Organic Chemistry, Beilstein-Institut, 2017, 13, pp.2115-2121. ⟨10.3762/bjoc.13.208⟩. ⟨hal-01631917⟩

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