Chemical analysis of the Alphaproteobacterium strain MOLA1416 associated with the marine lichen Lichina pygmaea

Abstract : Alphaproteobacterium strain MOLA1416, related to Mycoplana ramosa DSM 7292 and Chelativorans intermedius CC-MHSW-5 (93.6% 16S rRNA sequence identity) was isolated from the marine lichen, Lichina pygmaea and its chemical composition was characterized by a metabolomic network analysis using LC-MS/MS data. Twenty-five putative different compounds were revealed using a dereplication workflow based on MS/MS signatures available through GNPS (https://gnps.ucsd.edu/). In total, ten chemical families were highlighted including isocoumarins, macrolactones, erythrinan alkaloids, prodiginines, isoflavones, cyclohexane-diones, sterols, diketopiperazines, amino-acids and most likely glucocorticoids. Among those compounds, two known metabolites (13 and 26) were isolated and structurally identified and metabolite 26 showed a high cytotoxic activity against B16 melanoma cell lines with an IC50 0.6 ± 0.07 μg/mL. © 2017 Elsevier Ltd
Type de document :
Article dans une revue
Phytochemistry, Elsevier, 2018, 145, pp.57-67. 〈10.1016/j.phytochem.2017.10.005〉
Domaine :
Liste complète des métadonnées

https://hal-univ-rennes1.archives-ouvertes.fr/hal-01639693
Contributeur : Laurent Jonchère <>
Soumis le : lundi 20 novembre 2017 - 15:13:48
Dernière modification le : vendredi 25 mai 2018 - 01:26:28

Identifiants

Citation

D. Parrot, L. Intertaglia, P. Jéhan, M. Grube, M.T. Suzuki, et al.. Chemical analysis of the Alphaproteobacterium strain MOLA1416 associated with the marine lichen Lichina pygmaea. Phytochemistry, Elsevier, 2018, 145, pp.57-67. 〈10.1016/j.phytochem.2017.10.005〉. 〈hal-01639693〉

Partager

Métriques

Consultations de la notice

103