Iron overload: Diagnosis, complications, and management

Abstract : Chronic iron overload corresponds to a variety of genetic and acquired diseases. Genetic iron overload encompasses HFE and non-HFE-related hemochromatoses. Acquired iron overload is mainly due to multiple transfusions and to dyserythropoiesis. The damaging effect of iron excess concerns numerous organs and can therefore lead to miscellaneous clinical features, related especially to the liver, heart, pancreas, and rheumatological complications. Those complications alter not only the quality of life but also life expectancy. The diagnostic approach has become essentially noninvasive. It rests – beside clinical examination – on serum iron parameters (especially ferritin and transferrin saturation), on iron MRI, and, whenever indicated, on genetic testing. The treatment, in hepcidin deficiency-related iron overload, remains based on venesection therapy but should resort in the future to hepcidin supplementation. Posttransfusional iron overload has greatly benefited from the design of oral iron chelators.
Type de document :
Chapitre d'ouvrage
Abutalib S.; Connors J.; Ragni M. (eds). Iron overload: Diagnosis, complications, and management, Springer International Publishing, pp.103-112, 2016, 9783319303529; 9783319303505. 〈10.1007/978-3-319-30352-9_11〉
Liste complète des métadonnées

https://hal-univ-rennes1.archives-ouvertes.fr/hal-01639854
Contributeur : Laurent Jonchère <>
Soumis le : lundi 20 novembre 2017 - 16:21:24
Dernière modification le : mercredi 16 mai 2018 - 11:23:31

Identifiants

Citation

P. Brissot. Iron overload: Diagnosis, complications, and management. Abutalib S.; Connors J.; Ragni M. (eds). Iron overload: Diagnosis, complications, and management, Springer International Publishing, pp.103-112, 2016, 9783319303529; 9783319303505. 〈10.1007/978-3-319-30352-9_11〉. 〈hal-01639854〉

Partager

Métriques

Consultations de la notice

26