Association of light-to-moderate alcohol drinking in pregnancy with preterm birth and birth weight: elucidating bias by pooling data from nine European cohorts

Abstract : Women who drink light-to-moderately during pregnancy have been observed to have lower risk of unfavourable pregnancy outcomes than abstainers. This has been suggested to be a result of bias. In a pooled sample, including 193 747 live-born singletons from nine European cohorts, we examined the associations between light-to-moderate drinking and preterm birth, birth weight, and small-for-gestational age in term born children (term SGA). To address potential sources of bias, we compared the associations from the total sample with a sub-sample restricted to first-time pregnant women who conceived within six months of trying, and examined whether the associations varied across calendar time. In the total sample, drinking up to around six drinks per week as compared to abstaining was associated with lower risk of preterm birth, whereas no significant associations were found for birth weight or term SGA. Drinking six or more drinks per week was associated with lower birth weight and higher risk of term SGA, but no increased risk of preterm birth. The analyses restricted to women without reproductive experience revealed similar results. Before 2000 approximately half of pregnant women drank alcohol. This decreased to 39% in 2000–2004, and 14% in 2005–2011. Before 2000, every additional drink was associated with reduced mean birth weight, whereas in 2005–2011, the mean birth weight increased with increasing intake. The period-specific associations between low-to-moderate drinking and birth weight, which also were observed for term SGA, are indicative of bias. It is impossible to distinguish if the bias is attributable to unmeasured confounding, which change over time or cohort heterogeneity. © 2017, Springer Science+Business Media B.V.
Type de document :
Article dans une revue
European Journal of Epidemiology, Springer Verlag, 2017, 32 (9), pp.751-764. 〈10.1007/s10654-017-0323-2〉
Liste complète des métadonnées

Littérature citée [35 références]  Voir  Masquer  Télécharger

https://hal-univ-rennes1.archives-ouvertes.fr/hal-01647159
Contributeur : Xavier Chard-Hutchinson <>
Soumis le : vendredi 9 mars 2018 - 14:38:23
Dernière modification le : mercredi 18 juillet 2018 - 20:02:03
Document(s) archivé(s) le : dimanche 10 juin 2018 - 14:28:22

Fichier

Strandberg-Larsen - Chicos lig...
Fichiers produits par l'(les) auteur(s)

Identifiants

Citation

K. Strandberg-Larsen, G. Poulsen, B. Hammer Bech, L. Chatzi, S. Cordier, et al.. Association of light-to-moderate alcohol drinking in pregnancy with preterm birth and birth weight: elucidating bias by pooling data from nine European cohorts. European Journal of Epidemiology, Springer Verlag, 2017, 32 (9), pp.751-764. 〈10.1007/s10654-017-0323-2〉. 〈hal-01647159〉

Partager

Métriques

Consultations de la notice

415

Téléchargements de fichiers

18