Selective and Efficient Iridium Catalyst for the Reductive Amination of Levulinic Acid into Pyrrolidones

Shengdong Wang (1) , Haiyun Huang , Christian Bruneau (1) , Cedric Fischmeister (1)

1 ISCR - Institut des Sciences Chimiques de Rennes

The catalytic reductive amination of levulinic acid (LA) into pyrrolidones with an iridium catalyst using H2 as hydrogen source is reported. The chemoselective iridium catalyst displayed high efficiency for the synthesis of a variety of N-substituted 5-methyl-2-pyrrolidones and N-arylisoindolinones. N-Substituted 5-methyl-2-pyrrolidone was evaluated as a bio-sourced substitute solvent to NMP (N-Methyl-pyrrolidone) in the catalytic arylation of 2-phenylpyridine.

Keywords: biomass conversion; amination; heterocycles; homogeneous catalysis; iridium

Domains: Chemical Sciences; Catalysis; Chemical Sciences; Organic chemistry

Shengdong Wang, Haiyun Huang, Christian Bruneau, Cedric Fischmeister. Selective and Efficient Iridium Catalyst for the Reductive Amination of Levulinic Acid into Pyrrolidones. ChemSusChem, 2017, 10 (21), pp.4150-4154. ⟨10.1002/cssc.201701299⟩. ⟨hal-01653156⟩