Place de la témocilline dans le traitement des infections urinaires [Temocillin and urinary tract infections]

Résumé : Introduction. - Temocillin is an alternative to treat urinary tract infections with bacteria producing extended spectrum beta-lactamase (ESBL). The objective is to evaluate the use of temocillin in urinary tract infections. Materials and methods. - A systematic review of literature was carried out according to PRISMA criteria. All national and international recommendations have been reviewed regarding the indication of the use of temocillin in urology. Data collection on the use of temocillin in urinary tract infection has been performed from the Cochrane, LILACS and the Medline database. The following keywords were used: temocillin, extended spectrum. beta-lactamase, urinary tract infections, urine, prostate, epididymis, testis, diffusion, pharmacokinetics, pharmacodynamics. The selection was based on the methodology, language of publication (English/French), relevance to the topic and date of publication of the articles collected. The endpoint was to provide exhaustive scientific information allowing urologists to use this antibiotic in febrile urinary infections. Results. - Bacteria producing ESBL has a relatively high susceptible to temocillin, ranging from 61 % to 90 %. These rates would allow its use in probabilistic. The dosage recommended is currently, in the normo-renal patient, 4 g per day by intermittent infusion or continuously after a loading dose of 2g. Some studies argue, particularly in case of difficult clinical situations or obese patients, for administration of high doses (6 g/24 h) rather continuous infusion. There is no evident relationship between high doses and side effects. With an excellent urinary and prostatic diffusion, temocilllin might be recommend for the treatment of ESBL prostatitis. Conclusion. - Temocillin is known to have good urinary and prostatic diffusion. According to our results, this antibiotics is now a reliable alternative for the treatment of documented ESBL urinary tract infections. (C) 2017 Elsevier Masson SAS. All rights reserved.
Type de document :
Article dans une revue
Progrès en Urologie, Elsevier Masson, 2017, 27 (12), pp.609-617. 〈10.1016/j.purol.2017.07.242〉
Liste complète des métadonnées

https://hal-univ-rennes1.archives-ouvertes.fr/hal-01659245
Contributeur : Xavier Chard-Hutchinson <>
Soumis le : vendredi 8 décembre 2017 - 11:23:45
Dernière modification le : samedi 24 mars 2018 - 01:38:00

Identifiants

Citation

M. Vallee, F. Bruyere, F. Roblot, L. Brureau. Place de la témocilline dans le traitement des infections urinaires [Temocillin and urinary tract infections]. Progrès en Urologie, Elsevier Masson, 2017, 27 (12), pp.609-617. 〈10.1016/j.purol.2017.07.242〉. 〈hal-01659245〉

Partager

Métriques

Consultations de la notice

51