Is room temperature susceptometer really an accurate method to assess hepatocellular iron?

Anita Paisant (1, 2) , Fabrice Lainé (2, 3) , Yves Gandon (1) , Edouard Bardou-Jacquet (2, 3)

1 Département de Radiologie [CHU de Rennes]
2 CIC - Centre d'Investigation Clinique [Rennes]
3 CHU Pontchaillou [Rennes]

We read with interest the study by Mueller et al. describing the use of room temperature susceptometer (RTS) to assess hepatic iron content (HIC).1 This is an interesting clinical application of the methods described by Avrin et al.2,3 This topic is relevant as there is still a need for a cost-effective and efficient iron quantification method in liver disease.However, we think that several points could benefit from clarification and that a more cautious conclusion should be drawn from these results. Overall, as a study of diagnostic accuracy, it would have been beneficial to follow the STARD statement to avoid some pitfalls

Domains: Life Sciences [q-bio]; Bioengineering; Imaging; Life Sciences [q-bio]; Human health and pathology; Hépatology and Gastroenterology

Anita Paisant, Fabrice Lainé, Yves Gandon, Edouard Bardou-Jacquet. Is room temperature susceptometer really an accurate method to assess hepatocellular iron?. Journal of Hepatology, 2017, 67 (6), pp.1345-1346. ⟨10.1016/j.jhep.2017.07.021⟩. ⟨hal-01670794⟩