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Practical (asymmetric) transfer hydrogenation of ketones catalyzed by manganese with (chiral) diamines ligands

Abstract : The reduction of ketones with 2-propanol as reductant was achieved using an in-situ generated catalytic system based on manganese pentacarbonyl bromide, as metal precursor, and ethylenediamine as ligand. The reaction proceeds in high yield at 80 °C, in 3 h, with 0.5 mol% of catalyst. In the presence of chiral (1R,2R)-N,N′-dimethyl-1,2-diphenylethane-1,2-diamine, as the ligand, sterically hindered alcohols were produced with enantiomeric excess up to 90%.
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Submitted on : Friday, March 16, 2018 - 12:19:23 PM
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D. Wang, A. Bruneau-Voisine, J.-B. Sortais. Practical (asymmetric) transfer hydrogenation of ketones catalyzed by manganese with (chiral) diamines ligands. Catalysis Communications, Elsevier, 2018, 105, pp.31-36. ⟨10.1016/j.catcom.2017.10.028⟩. ⟨hal-01671636⟩

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