Gold-Catalyzed Synthesis of Substituted 3-Trifluoromethylpyrroles from Mesylated Amino Trifluoromethylpropargylic Alcohols

Benjamin Guieu (1) , Myriam Le Roch (1) , Michèle David (1) , Nicolas Gouault (1)

1 ISCR - Institut des Sciences Chimiques de Rennes

A series of substituted 3-trifluoromethylpyrroles was obtained from trifluoromethylamino-ynol derivatives via a gold-catalyzed cyclization. Using fluorinated starting materials, after mesylation, allowed for the desired compounds to be obtained in good yields under mild conditions.

Domains: Chemical Sciences; Organic chemistry; Chemical Sciences; Catalysis

Benjamin Guieu, Myriam Le Roch, Michèle David, Nicolas Gouault. Gold-Catalyzed Synthesis of Substituted 3-Trifluoromethylpyrroles from Mesylated Amino Trifluoromethylpropargylic Alcohols. Journal of Organic Chemistry, 2017, 82 (24), pp.13708-13713. ⟨10.1021/acs.joc.7b02567⟩. ⟨hal-01680989⟩