Is Required for Panitumumab Efficacy in Patients With Metastatic Colorectal Cancer, Journal of Clinical Oncology, vol.26, issue.10, pp.1626-1634, 1623. ,
DOI : 10.1200/JCO.2007.14.7116
, https://www.cancer.org
ERBB Receptors: From Oncogene Discovery to Basic Science to Mechanism-Based Cancer Therapeutics, Cancer Cell, vol.25, issue.3, pp.282-303, 2014. ,
DOI : 10.1016/j.ccr.2014.02.025
URL : https://doi.org/10.1016/j.ccr.2014.02.025
A chromatin modifier genetic screen identifies SIRT2 as a modulator of response to targeted therapies through the regulation of MEK kinase activity, Oncogene, vol.15, issue.4, p.588, 2014. ,
DOI : 10.1016/j.ccr.2009.02.023
Tumour gene expression predicts response to cetuximab in patients with KRAS wild-type metastatic colorectal cancer, British Journal of Cancer, vol.9, issue.3, pp.488-495, 2011. ,
DOI : 10.1126/science.1073096
URL : http://www.nature.com/bjc/journal/v104/n3/pdf/6606054a.pdf
Molecular Mechanisms of Resistance to Cetuximab and Panitumumab in Colorectal Cancer, Journal of Clinical Oncology, vol.28, issue.7, pp.1254-1261, 1225. ,
DOI : 10.1200/JCO.2009.24.6116
A Molecularly Annotated Platform of Patient-Derived Xenografts ("Xenopatients") Identifies HER2 as an Effective Therapeutic Target in Cetuximab-Resistant Colorectal Cancer, Cancer Discovery, vol.1, issue.6, pp.508-523, 2011. ,
DOI : 10.1158/2159-8290.CD-11-0109
The genomic landscape of response to EGFR blockade in colorectal cancer, Nature, vol.486, issue.7572, pp.263-267, 2015. ,
DOI : 10.1038/nature09208
Fluorouracil, Leucovorin, and Oxaliplatin With and Without Cetuximab in the First-Line Treatment of Metastatic Colorectal Cancer, Journal of Clinical Oncology, vol.27, issue.5, pp.663-671, 1229. ,
DOI : 10.1200/JCO.2008.20.8397
Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis, The Lancet Oncology, vol.11, issue.8, pp.753-762, 2010. ,
DOI : 10.1016/S1470-2045(10)70130-3
RAS mutations in colorectal cancer, N Engl J Med, vol.369, issue.22, pp.2159-2160, 2013. ,
Expression of pEGFR and pAKT as response-predictive biomarkers for RAS wild-type patients to anti-EGFR monoclonal antibodies in metastatic colorectal cancers, British Journal of Cancer, vol.61, issue.4, pp.680-685, 2015. ,
DOI : 10.1093/annonc/mds620
URL : https://hal.archives-ouvertes.fr/hal-01241758
A study-level meta-analysis of efficacy data from head-to-head first-line trials of epidermal growth factor receptor inhibitors versus bevacizumab in patients with RAS wild-type metastatic colorectal cancer, European Journal of Cancer, vol.67, pp.11-20, 2016. ,
DOI : 10.1016/j.ejca.2016.07.019
The relevance of primary tumour location in patients with metastatic colorectal cancer: A meta-analysis of first-line clinical trials, European Journal of Cancer, vol.70, pp.87-98, 1029. ,
DOI : 10.1016/j.ejca.2016.10.007
, , 2014.
, Epiregulin gene expression as a biomarker of benefit from cetuximab in the treatment of advanced colorectal cancer, Br J Cancer, vol.110, issue.3, pp.648-655
Structural analysis of the catalytically inactive kinase domain of the human EGF receptor 3, Proceedings of the National Academy of Sciences, vol.60, issue.Pt 12 Pt 1, pp.21608-21613, 2009. ,
DOI : 10.1107/S0907444904019158
Safety and Pharmacokinetics/Pharmacodynamics of the First-in-Class Dual Action HER3/EGFR Antibody MEHD7945A in Locally Advanced or Metastatic Epithelial Tumors, Clinical Cancer Research, vol.21, issue.11, pp.2462-2470, 2015. ,
DOI : 10.1158/1078-0432.CCR-14-2412
Mutations and Benefit from Cetuximab in Advanced Colorectal Cancer, New England Journal of Medicine, vol.359, issue.17, pp.1757-1765, 2008. ,
DOI : 10.1056/NEJMoa0804385
Mutation Status Predict Disease Control in Metastatic Colorectal Cancer Patients Treated With Cetuximab, Journal of Clinical Oncology, vol.25, issue.22, pp.3230-3237, 2007. ,
DOI : 10.1200/JCO.2006.10.5437
Sex- and gender-specific disparities in colorectal cancer risk, World Journal of Gastroenterology, vol.21, issue.17, pp.5167-5175, 2015. ,
DOI : 10.1093/jnci/djj159
MET Signaling in Colon Cancer Stem-like Cells Blunts the Therapeutic Response to EGFR Inhibitors, Cancer Research, vol.74, issue.6, pp.1857-18690008, 1821. ,
DOI : 10.1158/0008-5472.CAN-13-2340-T
Location of Primary Tumor and Benefit From Anti-Epidermal Growth Factor Receptor Monoclonal Antibodies in Patients With RAS and BRAF Wild-Type Metastatic Colorectal Cancer, The Oncologist, vol.21, issue.8, pp.988-994, 2016. ,
DOI : 10.1634/theoncologist.2016-0084
Predictive role of BRAF mutations in patients with advanced colorectal cancer receiving cetuximab and panitumumab: A meta-analysis, European Journal of Cancer, vol.51, issue.5, pp.587-594, 2015. ,
DOI : 10.1016/j.ejca.2015.01.054
, , 2016.
, Final results and outcomes by prior bevacizumab exposure, skin toxicity, and hypomagnesaemia from ASPECCT: randomized phase 3 non-inferiority study of panitumumab versus cetuximab in chemorefractory wild-type KRAS exon 2 metastatic colorectal cancer, Eur J Cancer, vol.68, pp.51-59
A language and environment for statistical computing., R Foundation for Statistical Computing, 2015. ,
Broad Detection of Alterations, 2016. ,
, Karapetis CS and Sorich MJ, 2015.
, Meta-analysis of BRAF mutation as a predictive biomarker of benefit from anti-EGFR monoclonal antibody therapy for RAS wild-type metastatic colorectal cancer, Br J Cancer, vol.112, issue.12, pp.1888-1894
PIK3CA Mutations in Colorectal Cancer Are Associated with Clinical Resistance to EGFR-Targeted Monoclonal Antibodies, Cancer Research, vol.69, issue.5, pp.1851-1857, 2009. ,
DOI : 10.1158/0008-5472.CAN-08-2466
URL : http://cancerres.aacrjournals.org/content/69/5/1851.full.pdf
Wild-Type Advanced Colorectal Cancer, JAMA Oncology, vol.2, issue.5, 2016. ,
DOI : 10.1001/jamaoncol.2015.6065
Cetuximab-Induced MET Activation Acts as a Novel Resistance Mechanism in Colon Cancer Cells, International Journal of Molecular Sciences, vol.19, issue.4, pp.5838-5851, 2014. ,
DOI : 10.1158/1078-0432.CCR-13-0423
Wild-Type Metastatic Colorectal Cancer, JAMA Oncology, vol.3, issue.2, 2016. ,
DOI : 10.1001/jamaoncol.2016.3797
Dual targeting of HER3 and EGFR in colorectal tumors might overcome anti-EGFR resistance, Critical Reviews in Oncology/Hematology, vol.101, pp.151-158, 2016. ,
DOI : 10.1016/j.critrevonc.2016.03.009
New Guidelines to Evaluate the Response to Treatment in Solid Tumors, JNCI: Journal of the National Cancer Institute, vol.92, issue.3, pp.205-216, 2000. ,
DOI : 10.1093/jnci/91.6.523
Increased TGF-?? as a Mechanism of Acquired Resistance to the Anti-EGFR Inhibitor Cetuximab through EGFR-MET Interaction and Activation of MET Signaling in Colon Cancer Cells, Clinical Cancer Research, vol.19, issue.24, pp.6751-6765, 2013. ,
DOI : 10.1158/1078-0432.CCR-13-0423
, , 2012.
, NormaCurve: a SuperCurve-based method that simultaneously quantifies and normalizes reverse phase protein array data, PLoS One, vol.7, issue.6, pp.38686-32012
, Nippgen J and Rougier P, 2009.
, Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer, N Engl J Med, vol.360, issue.14, pp.1408-1417
Acquired resistance to EGFR-targeted therapies in??colorectal cancer, Molecular Oncology, vol.3, issue.6, pp.96-00099, 2014. ,
DOI : 10.1126/scitranslmed.3002442
Epidermal Growth Factor Receptor Activity Determines Response of Colorectal Cancer Cells to Gefitinib Alone and in Combination with Chemotherapy, Clinical Cancer Research, vol.11, issue.20, pp.7480-7489, 2005. ,
DOI : 10.1158/1078-0432.CCR-05-0328
,