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Journal articles
Synthesis of Polysubstituted Isoquinolines and Related Fused Pyridines from Alkenyl Boronic Esters via a Copper-Catalyzed Azidation/Aza-Wittig Condensation Sequence
Abstract : An efficient and straightforward synthesis of isoquinolines is reported from internal alkenyl boronic esters, easily prepared from the corresponding 1,2-bis(boronates), via a sequential copper-catalyzed azidation/aza-Wittig condensation. This synthetic method has been used to synthesize quinisocaine, a topical anesthetic used for the treatment of pain and pruritus, and further extended to thieno[2,3-c]pyridines by using 2-thiophenecarboxaldehyde as coupling partner in the first step.
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01709528
Contributor : Laurent Jonchère Connect in order to contact the contributor
Submitted on : Friday, April 27, 2018 - 11:19:42 AM
Last modification on : Tuesday, January 4, 2022 - 4:22:31 AM
Long-term archiving on: : Thursday, September 20, 2018 - 5:46:15 AM
Contributor : Laurent Jonchère Connect in order to contact the contributor
Submitted on : Friday, April 27, 2018 - 11:19:42 AM
Last modification on : Tuesday, January 4, 2022 - 4:22:31 AM
Long-term archiving on: : Thursday, September 20, 2018 - 5:46:15 AM