Palladium-Catalyzed Cross-Coupling/Annulation Cascade for Synthesis of 9-Hydroxy and 9-Aminofluorenes

Benjamin Francois; Luc Szczubelek; Fabienne Berrée; Thierry Roisnel; Bertrand Carboni

doi:10.1002/adsc.201701146

Journal articles

Palladium-Catalyzed Cross-Coupling/Annulation Cascade for Synthesis of 9-Hydroxy and 9-Aminofluorenes

Benjamin Francois ¹ Luc Szczubelek ¹ Fabienne Berrée ¹ Thierry Roisnel ¹ Bertrand Carboni ¹

1 ISCR - Institut des Sciences Chimiques de Rennes

Abstract : 9-Hydroxyfluorenes are easily synthesized via a tandem Suzuki/phenolic aldolisation sequence. This process was extended to 9-amino-fluorenes by simply adding various amines as third partners. X-ray structures and NMR studies confirmed the presence of intermolecular O-H center dot center dot center dot N hydrogen bonding.

Keywords : Suzuki coupling Mannich reaction cascade process fluorene Betti bases

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Journal articles

Domain :

Chemical Sciences

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https://hal-univ-rennes1.archives-ouvertes.fr/hal-01709531
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Submitted on : Thursday, February 15, 2018 - 9:39:36 AM
Last modification on : Friday, July 10, 2020 - 4:00:47 PM

Palladium-Catalyzed Cross-Coupling/Annulation Cascade for Synthesis of 9-Hydroxy and 9-Aminofluorenes

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Palladium-Catalyzed Cross-Coupling/Annulation Cascade for Synthesis of 9-Hydroxy and 9-Aminofluorenes

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