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Assessing Ge-132 as an antioxidant in organic and water-containing media

Abstract : The antioxidant activity of Ge-132 (2-carboxyethylgermanium sesquioxide, [(O0.5)3GeCH2CH2COOH]n), a widely used organic germanium dietary supplement, was assessed by cyclic voltammetry and through its interaction with a stable radical 2,2,-diphenyl-1-picrylhydrazyl (DPPH) monitored by UV-Vis and EPR spectroscopy in water, CH3CN, DMF, MeOH, and their mixtures with water. The results obtained by these methods are coherent in that Ge-132 can manifest its antioxidant activity only in the absence of water because the latter hydrolyses its Ge-O-Ge fragment responsible for quenching free radicals. Thus, contrary to a common use of Ge-132 as a water-soluble agent, it can act as an antioxidant solely in a lipid environment, which is important for understanding the mechanism of its biological activity.
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Submitted on : Wednesday, April 25, 2018 - 4:13:48 PM
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A.A. Vishtorskaya, E.A. Saverina, V.M. Pechennikov, I.V. Krylova, A.V. Lalov, et al.. Assessing Ge-132 as an antioxidant in organic and water-containing media. Journal of Organometallic Chemistry, Elsevier, 2018, 858, pp.8-13. ⟨10.1016/j.jorganchem.2018.01.004⟩. ⟨hal-01713500⟩

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