Exploring the Antimicrobial Action of Quaternary Amines against Acinetobacter baumannii - Université de Rennes Accéder directement au contenu
Article Dans Une Revue mBio Année : 2018

Exploring the Antimicrobial Action of Quaternary Amines against Acinetobacter baumannii

Résumé

Quaternary amine compounds (QAC) are potent antimicrobials used to prevent the spread of pathogenic bacteria. While they are known for their membrane-damaging properties, QAC action has been suggested to extend beyond the surface to intracellular targets. Here we characterize the range of action of the QAC biocide benzalkonium chloride (BZK) against the bacterial pathogen At high concentrations, BZK acts through membrane disruption, but at low concentrations we show that wide-spread protein aggregation is associated with BZK-induced cell death. Resistance to BZK is found to develop through ribosomal protein mutations that protect against BZK-induced protein aggregation. The multifunctional impact of BZK led us to discover that alternative QAC structures, with low human toxicity, retain potent action against multidrug-resistant , , and and present opportunities for their development as antibiotics. Quaternary amine compounds (QACs) are widely used to prevent the spread of bacterial pathogens, but our understanding of their mode of action is incomplete. Here we describe disruption of bacterial proteostasis as an unrecognized action of QAC antimicrobial action and uncover the potential of diverse QAC structures to act as multitarget antibiotics.
Fichier principal
Vignette du fichier
e02394-17.full.pdf (2.2 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte
Loading...

Dates et versions

hal-01718048 , version 1 (09-10-2018)

Identifiants

Citer

Gregory A. Knauf, Ashley L. Cunningham, Misha I. Kazi, Ian M. Riddington, Alexander A. Crofts, et al.. Exploring the Antimicrobial Action of Quaternary Amines against Acinetobacter baumannii. mBio, 2018, 9 (1), pp.e02394-17. ⟨10.1128/mBio.02394-17⟩. ⟨hal-01718048⟩
140 Consultations
177 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More