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, Amounts of Flag-tagged GABAB2 mutants at the cell surface were quantified by ELISA in intact (i.e. non-permeabilized) cells using the Flag epitope at the extracellular N-terminus of the GABAB2 subunit. Data are expressed as means ± SEM of triplicates from a typical experiment repeated at least three times. E) Inositol-phosphate accumulation mediated by the wild-type and mutant Flag-tagged GABAB2 co-expressed with the wild-type GABAB1a and G?qi9, as in panel B. The GABAB receptor wild-type and GABAB mutants were incubated with 100 µM GABA, 10 µM CGP54626 or both, GABAB2 mutants when co-expressed with the wild-type GABAB1a

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