F. Braun, N. Bertolettin, G. Möller, J. Adamski, T. Steinmetzer et al., First Structure???Activity Relationship of 17??-Hydroxysteroid Dehydrogenase Type 14 Nonsteroidal Inhibitors and Crystal Structures in Complex with the Enzyme, Journal of Medicinal Chemistry, vol.59, issue.23, pp.10719-10737
DOI : 10.1021/acs.jmedchem.6b01436

G. C. Byrne, Y. S. Perry, and J. S. Winter, Kinetic Analysis of Adrenal 3??-Hydroxysteroid Dehydrogenase Activity During Human Development*, The Journal of Clinical Endocrinology & Metabolism, vol.60, issue.5, pp.934-939, 1985.
DOI : 10.1210/jcem-60-5-934

C. Chen, Physicochemical, Pharmacological and Pharmacokinetic Properties of the Zwitterionic Antihistamines Cetirizine and Levocetirizine, Current Medicinal Chemistry, vol.15, issue.21, pp.2173-2191, 2008.
DOI : 10.2174/092986708785747625

M. Church, K. Maurer, and M. , Antihistamines. Chem. Immunol. Allergy, vol.100, 2014.

G. J. Digregorio and E. Ruch, Human whole blood and parotid saliva concentrations of oral and intramuscular promethazine, Journal of Pharmaceutical Sciences, vol.69, issue.12, pp.1457-1459, 1980.
DOI : 10.1002/jps.2600691234

D. F. Fan and P. Troen, Studies of the Human Testis. VII. Conversion of Pregnenolone to Progesterone, The Journal of Clinical Endocrinology & Metabolism, vol.41, issue.3, 1975.
DOI : 10.1210/jcem-41-3-563

C. H. Hansen, L. W. Larsen, A. M. Sørensen, B. Halling-sørensen, and B. Styrishave, The six most widely used selective serotonin reuptake inhibitors decrease androgens and increase estrogens in the H295R cell line, Toxicology in Vitro, vol.41, pp.1-11, 2017.
DOI : 10.1016/j.tiv.2017.02.001

P. W. Harvey and D. J. Everett, The adrenal cortex and steroidogenesis as cellular and molecular targets for toxicity: critical omissions from regulatory endocrine disrupter screening strategies for human health?, Journal of Applied Toxicology, vol.76, issue.2, pp.81-87, 2003.
DOI : 10.1007/s00204-002-0371-5

K. Hilscherova, P. D. Jones, T. Gracia, J. L. Newsted, X. Zhang et al., Assessment of the Effects of Chemicals on the Expression of Ten Steroidogenic Genes in the H295R Cell Line Using Real-Time PCR, Toxicological Sciences, vol.81, issue.1, pp.78-89, 2004.
DOI : 10.1093/toxsci/kfh191

C. P. Houk, E. J. Pearson, N. Martinelle, P. K. Donahoe, and J. Teixeira, by Androgens, Endocrinology, vol.145, issue.3, pp.1269-1275, 2004.
DOI : 10.1210/en.2003-1046

A. C. , , p.17

A. Danish-health, ATC-grupe R06 -Antihistaminer Retrieved from http://www.irf.dk/dk/rekommandationsliste/baggrundsnotater/aandedraetsorganer/atc- gruppe_r06_96_antihistaminer.htm Jones, A.W. 2016. Perspectives in Drug Development and Clinical Pharmacology: The Discovery of Histamine H1 and H2 Antagonists, Clin. Pharmacol. Drug Dev, vol.5, pp.5-12, 2009.

B. Källén and P. O. Olausson, Monitoring of maternal drug use and infant congenital malformations. Does loratadine cause hypospadias?, Int. J. Risk Saf. Med, vol.14, pp.115-119, 2001.

B. Kaminska, J. Czerwinska, B. Wojciechowicz, A. Nynca, and R. Ciereszko, Genistein and daidzein affect in vitro steroidogenesis but not gene expression of steroidogenic enzymes in adrenals of pigs, J. Physiol. Pharmacol, vol.65, pp.127-133, 2014.

A. M. Mahdy and N. R. Webster, Histamine and antihistamines. Anaesthesia Intens, Care Med, vol.12, pp.324-329, 2011.

J. Mason, R. Reynolds, and N. Rao, The systemic safety of fexofenadine HCl, Clinical & Experimental Allergy, vol.78, issue.Suppl., pp.163-170, 1999.
DOI : 10.1016/S0091-6749(96)80192-8

B. S. Mcintyre, P. M. Vancutsem, K. A. Treinen, and R. E. Morrissey, Effects of perinatal loratadine exposure on male rat reproductive organ development, Reproductive Toxicology, vol.17, issue.6, pp.691-697, 2003.
DOI : 10.1016/S0890-6238(03)00108-4

M. Molimard, B. Diquet, and M. S. Benedetti, Comparison of pharmacokinetics and metabolism of desloratadine, fexofenadine, levocetirizine and mizolastine in humans, Fundamental and Clinical Pharmacology, vol.39, issue.4, 2004.
DOI : 10.1111/j.1365-2125.1995.tb04406.x

D. G. Ndossi, C. Frizzell, N. H. Tremoen, C. K. Faeste, S. Verhaegen et al., An in vitro investigation of endocrine disrupting effects of trichothecenes deoxynivalenol (DON), T-2 and HT-2 toxins, Toxicology Letters, vol.214, issue.3, pp.268-278, 2012.
DOI : 10.1016/j.toxlet.2012.09.005

J. Nicolas, R. Whomsley, C. Collart, and J. Roba, In vitro inhibition of human liver drug metabolizing enzymes by second generation antihistamines, Chemico-Biological Interactions, vol.123, issue.1, pp.63-79, 1999.
DOI : 10.1016/S0009-2797(99)00131-3

F. K. Nielsen, C. H. Hansen, J. A. Fey, M. Hansen, N. W. Jacobsen et al., H295R cells as a model for steroidogenic disruption: A broader perspective using simultaneous chemical analysis of 7 key steroid hormones, Toxicology in Vitro, vol.26, issue.2, 2012.
DOI : 10.1016/j.tiv.2011.12.008

O. 'brien, J. Wilson, I. Orton, T. Pognan, and F. , Investigation of the Alamar Blue (resazurin) fluorescent dye for the assessment of mammalian cell cytotoxicity, European Journal of Biochemistry, vol.107, issue.17, pp.5421-5426, 2000.
DOI : 10.1016/0009-8981(80)90442-8

O. , , 2011.

S. Ohno, N. Matsumoto, M. Watanabe, and S. Nakajin, Flavonoid inhibition of overexpressed human 3beta-hydroxysteroid dehydrogenase type II, J. Steroid Biochem. Mol. Biol, vol.88, 2004.
DOI : 10.1016/j.jsbmb.2003.11.007

S. Ohno, S. Shinoda, S. Toyoshima, H. Nakazawa, T. Makino et al., Effects of flavonoid phytochemicals on cortisol production and on activities of steroidogenic enzymes in human adrenocortical H295R cells, The Journal of Steroid Biochemistry and Molecular Biology, vol.80, issue.3, pp.355-363, 2002.
DOI : 10.1016/S0960-0760(02)00021-3

T. M. Penning, Molecular Endocrinology of Hydroxysteroid Dehydrogenases, Endocrine Reviews, vol.18, issue.3, pp.281-305, 1997.
DOI : 10.1210/er.18.3.281

J. M. Portnoy and C. Dinakar, Review of cetirizine hydrochloride for the treatment of allergic disorders, Expert Opinion on Pharmacotherapy, vol.5, issue.4, 2004.
DOI : 10.1038/sj.bjp.0701879

W. E. Rainey, I. M. Bird, C. Sawetawan, N. A. Hanley, J. L. Mccarthy et al., Regulation of human adrenal carcinoma cell (NCI-H295) production of C19 steroids, J. Clin. Endocrinol. Metab, vol.77, pp.731-737, 1993.

J. M. Reul, I. Stec, M. Soder, and F. Holsboer, Chronic treatment of rats with the antidepressant amitriptyline attenuates the activity of the hypothalamic-pituitary-adrenocortical system. Endocrin, 1993.

A. C. , , p.18

D. K. Robbins, M. A. Castles, D. J. Pack, V. O. Bhargava, and S. J. Weir, Dose proportionality and comparison of single and multiple dose pharmacokinetics of fexofenadine (MDL 16???455) and its enantiomers in healthy male volunteers, Biopharmaceutics & Drug Disposition, vol.19, issue.7, pp.455-463, 1998.
DOI : 10.1002/(SICI)1099-081X(199810)19:7<455::AID-BDD130>3.0.CO;2-W

T. Russell, M. Stoltz, and S. Weir, Pharmacokinetics, pharmacodynamics, and tolerance of single- and multiple-dose fexofenadine hydrochloride in healthy male volunteers, Clinical Pharmacology & Therapeutics, vol.46, issue.6, pp.612-621, 1998.
DOI : 10.1177/019459989411100138

J. T. Sanderson, J. T. Sanderson, J. Boerma, G. W. Lansbergen, and M. Van-den-berg, The steroid hormone biosynthesis pathway as a target for endocrine-disrupting chemicals Induction and inhibition of aromatase (CYP19) activity by various classes of pesticides in H295R human adrenocortical carcinoma cells, Tox. Sci. Tox. Applied Pharmacol, vol.94, issue.182, pp.44-54, 2002.

R. M. Shawky and N. S. Seifeldin, The relation between antihistamine medication during early pregnancy & birth defects, Egyptian Journal of Medical Human Genetics, vol.16, issue.4, pp.287-290, 2015.
DOI : 10.1016/j.ejmhg.2015.04.003

F. E. Simons and K. J. Simons, H1 Antihistamines, World Allergy Organization Journal, vol.1, issue.9, pp.145-155, 2008.
DOI : 10.1097/WOX.0b013e318186fb3a

K. Simpson and B. Jarvis, Fexofenadine, Drugs, vol.37, issue.1, pp.301-321, 2000.
DOI : 10.3928/0090-4481-19981101-07

M. So, P. Bozzo, M. Inoue, and A. Einarson, Safety of antihistamines during pregnancy and lactation, Can. Family Physician, vol.56, pp.427-429, 2010.

B. Staels, D. W. Hum, and W. L. Miller, Regulation of steroidogenesis in NCI-H295 cells: a cellular model of the human fetal adrenal, Mol. Endocrinol, vol.7, pp.423-433, 1993.

S. Sørensen, A. M. Hansen, C. H. Bonomo, S. Olsen, L. Jørgensen et al., Enantioselective endocrine disrupting effects of omeprazole studied in the H295R cell assay and by molecular modeling, Toxicology in Vitro, vol.34, pp.71-80, 2016.
DOI : 10.1016/j.tiv.2016.03.007

G. Taylor, J. B. Houston, J. Shaffer, G. J. Mawer, C. H. Hansen et al., Pharmacokinetics of promethazine and its sulphoxide metabolite after intravenous and oral administration to man., British Journal of Clinical Pharmacology, vol.27, issue.3, pp.287-293, 1007.
DOI : 10.1038/clpt.1980.4

E. Willingham, K. Agras, M. Vilela, and L. S. Baskin, Loratadine Exerts Estrogen-Like Effects and Disrupts Penile Development in the Mouse, The Journal of Urology, vol.175, issue.2, pp.723-726, 2006.
DOI : 10.1016/S0022-5347(05)00188-6