miRNA displacement as a promising approach for cancer therapy

David Gilot (1) , Marie-Dominique Galibert (1, 2)

1 IGDR - Institut de Génétique et Développement de Rennes
2 CHU Pontchaillou [Rennes]

microRNA (miRNA) are critical post-transcriptional regulators and key players in diseases development. We demonstrated that non-canonical microRNA Responsive Elements (here MRE-16) could sequester miR-16, dampening miR-16 tumor suppressor function. We developed small oligonucleotides, masking specifically these unusual miR-16 binding sites, that restored miR-16 function. This constitutes a promising targeted approach.

Keywords: antisense oligonucleotides; melanoma; miRNA; TYRP1

Domains: Life Sciences [q-bio]; Genetics

David Gilot, Marie-Dominique Galibert. miRNA displacement as a promising approach for cancer therapy. Molecular & Cellular Oncology, 2018, 5 (1), pp.e1406432. ⟨10.1080/23723556.2017.1406432⟩. ⟨hal-01730312⟩