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miRNA displacement as a promising approach for cancer therapy

Abstract : microRNA (miRNA) are critical post-transcriptional regulators and key players in diseases development. We demonstrated that non-canonical microRNA Responsive Elements (here MRE-16) could sequester miR-16, dampening miR-16 tumor suppressor function. We developed small oligonucleotides, masking specifically these unusual miR-16 binding sites, that restored miR-16 function. This constitutes a promising targeted approach.
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https://hal-univ-rennes1.archives-ouvertes.fr/hal-01730312
Contributor : Xavier Chard-Hutchinson <>
Submitted on : Tuesday, March 13, 2018 - 10:56:51 AM
Last modification on : Wednesday, September 5, 2018 - 4:02:37 PM

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David Gilot, Marie-Dominique Galibert. miRNA displacement as a promising approach for cancer therapy. Molecular & Cellular Oncology, Taylor et Francis, 2018, 5 (1), pp.e1406432. ⟨10.1080/23723556.2017.1406432⟩. ⟨hal-01730312⟩

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