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Article Dans Une Revue Molecular & Cellular Oncology Année : 2018

miRNA displacement as a promising approach for cancer therapy

Résumé

microRNA (miRNA) are critical post-transcriptional regulators and key players in diseases development. We demonstrated that non-canonical microRNA Responsive Elements (here MRE-16) could sequester miR-16, dampening miR-16 tumor suppressor function. We developed small oligonucleotides, masking specifically these unusual miR-16 binding sites, that restored miR-16 function. This constitutes a promising targeted approach.

Domaines

Génétique

Dates et versions

hal-01730312 , version 1 (13-03-2018)

Identifiants

Citer

David Gilot, Marie-Dominique Galibert. miRNA displacement as a promising approach for cancer therapy. Molecular & Cellular Oncology, 2018, 5 (1), pp.e1406432. ⟨10.1080/23723556.2017.1406432⟩. ⟨hal-01730312⟩
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