Occupational exposure to textile dust and lung cancer risk Results from the ICARE Study

Soumaya Ben Khedher; Monica Neri; Florence Guida; Mireille Matrat; Sylvie Cenée; Marie Sanchez; Loredana Radoï; Gwenn Menvielle; Emilie Marrer; Danièle Luce; Isabelle Stücker

doi:10.1002/ajim.22799

Journal articles

Occupational exposure to textile dust and lung cancer risk Results from the ICARE Study

Soumaya Ben Khedher ^{1, *} Monica Neri ² Florence Guida ^{2, 3} Mireille Matrat ^{2, 4, 5} Sylvie Cenée ² Marie Sanchez ² Loredana Radoï ^{2, 6} Gwenn Menvielle ⁷ Emilie Marrer ⁸ Danièle Luce ^{9, 10} Isabelle Stücker ²

* Corresponding author

1 Université Paris-Saclay

2 CESP - Centre de recherche en épidémiologie et santé des populations

3 CIRC - IARC - Centre International de Recherche contre le Cancer - International Agency for Research on Cancer

4 CHI Créteil

5 Im3 - Institut Mondor de médecine moléculaire

6 UPD5 Odontologie - Université Paris Descartes - Faculté de Chirurgie Dentaire

7 iPLESP - Institut Pierre Louis d'Epidémiologie et de Santé Publique

8 CH E.Muller Mulhouse - Centre Hospitalier Emile Muller [Mulhouse]

9 Irset - Institut de recherche en santé, environnement et travail

10 UR1 - Université de Rennes 1

Abstract : Background - To investigate the association of lung cancer with occupational exposure to textile dust and specifically to cotton dust in the population-based case-control study ICARE. Methods - Lifelong occupational history of 2926 cases and 3555 controls was collected using standardized questionnaires, with specific questions for textile dust exposure. Odds ratios (ORs) and 95% confidence intervals (CI) were estimated using unconditional logistic regression models controlling for confounding factors including smoking and asbestos exposure. Results - An inverse association between textile dust exposure and lung cancer was found among workers exposed ≥5% of their work time (OR = 0.80, 95%CI = 0.58-1.09), more pronounced for distant exposures (40+ years; up to a 56% reduced risk, statistically significant). The OR of lung cancer was significantly decreased among workers exposed to cotton fibers (OR = 0.70, 95%CI = 0.48-0.97). Conclusions - Our results provide some evidence of a decreased risk of lung cancer associated with exposure to textile dust, particularly cotton.

Keywords : case-control studies endotoxin etiology lung cancer textile dust

Document type :

Journal articles

Domain :

Life Sciences [q-bio] / Ecology, environment / Health

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https://hal-univ-rennes1.archives-ouvertes.fr/hal-01730385
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Submitted on : Tuesday, March 13, 2018 - 11:32:41 AM
Last modification on : Wednesday, October 20, 2021 - 3:19:22 AM

Occupational exposure to textile dust and lung cancer risk Results from the ICARE Study

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