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Towards a patient-specific hepatic arterial modeling for microspheres distribution optimization in SIRT protocol

Abstract : Selective internal radiation therapy (SIRT) using Yttrium-90 loaded glass microspheres injected in the hepatic artery is an emerging, minimally invasive therapy of liver cancer. A personalized intervention can lead to high concentration dose in the tumor, while sparing the surrounding parenchyma. We propose a computational model for patient-specific simulation of entire hepatic arterial tree, based on liver, tumors, and arteries segmentation on patient’s tomography. Segmentation of hepatic arteries down to a diameter of 0.5 mm is semi-automatically performed on 3D cone-beam CT angiography. The liver and tumors are extracted from CT-scan at portal phase by an active surface method. Once the images are registered through an automatic multimodal registration, extracted data are used to initialize a numerical model simulating liver vascular network. The model creates successive bifurcations from given principal vessels, observing Poiseuille’s and matter conservation laws. Simulations provide a coherent reconstruction of global hepatic arterial tree until vessel diameter of 0.05 mm. Microspheres distribution under simple hypotheses is also quantified, depending on injection site. The patient-specific character of this model may allow a personalized numerical approximation of microspheres final distribution, opening the way to clinical optimization of catheter placement for tumor targeting.
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Submitted on : Friday, April 13, 2018 - 11:33:13 AM
Last modification on : Monday, May 18, 2020 - 2:38:22 PM

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Costanza Simoncini, Krzysztof Jurczuk, Daniel Reska, Simon Esneault, Jean-Claude Nunes, et al.. Towards a patient-specific hepatic arterial modeling for microspheres distribution optimization in SIRT protocol. Medical and Biological Engineering and Computing, Springer Verlag, 2018, 56 (3), pp.515-529. ⟨10.1007/s11517-017-1703-1⟩. ⟨hal-01740212⟩

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