Skip to Main content Skip to Navigation
Journal articles

Lineage-Biased Hematopoietic Stem Cells Are Regulated by Distinct Niches

Abstract : The spatial localization of hematopoietic stem cells (HSCs) in the bone marrow (BM) remains controversial, with some studies suggesting that they are maintained in homogeneously distributed niches while others have suggested the contributions of distinct niche structures. Subsets of quiescent HSCs have been reported to associate with megakaryocytes (MK) or arterioles in the BM. However, these HSC subsets have not been prospectively defined. Here, we show that platelet and myeloid-biased HSCs, marked by von Willebrand factor (vWF) expression, are highly enriched in MK niches. Depletion of MK selectively expands vWFHSCs, whereas the depletion of NG2arteriolar niche cells selectively depletes vWFlymphoid-biased HSCs. In addition, MK depletion compromises vWFHSC function by reducing their long-term self-renewal capacity and eliminating their lineage bias after transplantation. These studies demonstrate the existence of two spatially and functionally separate BM niches for HSC subsets with distinct developmental potential.
Document type :
Journal articles
Complete list of metadatas

https://hal-univ-rennes1.archives-ouvertes.fr/hal-01742795
Contributor : Laurent Jonchère <>
Submitted on : Monday, March 26, 2018 - 9:39:55 AM
Last modification on : Wednesday, October 14, 2020 - 3:49:07 AM

Links full text

Identifiers

Citation

Sandra Pinho, Tony Marchand, Eva Yang, Qiaozhi Wei, Claus Nerlov, et al.. Lineage-Biased Hematopoietic Stem Cells Are Regulated by Distinct Niches. Developmental Cell, Elsevier, 2018, 44 (5), pp.634-641.e4. ⟨10.1016/j.devcel.2018.01.016⟩. ⟨hal-01742795⟩

Share

Metrics

Record views

128