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Prevalence and nature of statin drug-drug interactions in a university hospital by electronic health record mining

Abstract : Aim: Our aim was to describe prevalence, nature, and level of severity of potential statin drug-drug interactions in a university hospital. Methods: In a cross-sectional study, statin drug-drug interactions were screened from medical record of 10,506 in-patients treated stored in the clinical data warehouse “eHOP.” We screened drug-drug interactions using Theriaque and Micromedex drug databases. Results: A total of 22.5% of patients were exposed to at least one statin drug-drug interaction. Given their lipophilicity and CYP3A4 metabolic pathway, atorvastatin and simvastatin presented a higher prevalence of drug-drug interactions while fluvastatin presented the lowest prevalence. Up to 1% of the patients was exposed to a contraindicated drug-drug interaction, the most frequent drug-drug interaction involving influx-transporter (i.e., OATP1B1) interactions between simvastatin or rosuvastatin with cyclosporin. The second most frequent contraindicated drug-drug interaction involved CYP3A4 interaction between atorvastatin or simvastatin with either posaconazole or erythromycin. Furthermore, our analysis showed some discrepancies between Theriaque and Micromedex in the prevalence and the nature of drug-drug interactions. Conclusions: Different drug-drug interaction profiles were observed between statins with a higher prevalence of CYP3A4-based interactions for lipophilic statins. Analyzing the three most frequent DDIs, the more significant DDIs (level 1: contraindication) were reported for transporter-based DDI involving OATP1B1 influx transporter. These points are of concern to improve prescriptions of statins.
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Submitted on : Thursday, April 12, 2018 - 4:36:09 PM
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Camille Morival, Richard Westerlynck, Guillaume Bouzillé, Marc Cuggia, Pascal Le Corre. Prevalence and nature of statin drug-drug interactions in a university hospital by electronic health record mining. European Journal of Clinical Pharmacology, Springer Verlag, 2018, 74 (4), pp.525-534. ⟨10.1007/s00228-017-2400-6⟩. ⟨hal-01743767⟩

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