T. E. Owan, D. O. Hodge, and R. M. Herges, Trends in prevalence and outcome of heart failure with preserved ejection fraction, N Engl J Med, vol.355, pp.251-260, 2006.

M. R. Zile, J. S. Gottdiener, and S. J. Hetzel, Prevalence and significance of alterations in cardiac structure and function in patients with heart failure and a preserved ejection fraction, Circulation, vol.124, pp.2491-501, 2011.

M. R. Zile, C. F. Baicu, and W. H. Gaasch, Diastolic heart failure-abnormalities in active relaxation and passive stiffness of the left ventricle, N Engl J Med, vol.350, pp.1953-1962, 2004.

C. P. Liu, C. T. Ting, and W. Lawrence, Diminished contractile response to increased heart rate in intact human left ventricular hypertrophy. Systolic versus diastolic determinants, Circulation, vol.88, pp.1893-906, 1993.

M. M. Redfield, S. J. Jacobsen, and J. C. Burnett, Burden of systolic and diastolic ventricular dysfunction in the community: appreciating the scope of the heart failure epidemic, JAMA, vol.289, pp.194-202, 2003.

A. B. Santos, E. Kraigher-krainer, and D. K. Gupta, Impaired left atrial function in heart failure with preserved ejection fraction, Eur J Heart Fail, vol.16, pp.1096-103, 2014.

V. Melenovsky, S. J. Hwang, and M. M. Redfield, Left atrial remodeling and function in advanced heart failure with preserved or reduced ejection fraction, Circ Heart Fail, vol.8, pp.295-303, 2015.

C. S. Lam, V. L. Roger, and R. J. Rodeheffer, Cardiac structure and ventricular-vascular function in persons with heart failure and preserved ejection fraction from Olmsted County, Minnesota, Circulation, vol.115, pp.1982-90, 2007.

A. Rossi, M. Gheorghiade, and F. Triposkiadis, Left atrium in heart failure with preserved ejection fraction: structure, function, and significance, Circ Heart Fail, vol.7, pp.1042-1051, 2014.

V. Melenovsky, B. A. Borlaug, and B. Rosen, Cardiovascular features of heart failure with preserved ejection fraction versus nonfailing hypertensive left ventricular hypertrophy in the urban Baltimore community: the role of atrial remodeling/dysfunction, J Am Coll Cardiol, vol.49, pp.198-207, 2007.

W. J. Paulus and C. Tschope, A novel paradigm for heart failure with preserved ejection fraction: comorbidities drive myocardial dysfunction and remodeling through coronary microvascular endothelial inflammation, J Am Coll Cardiol, vol.62, pp.263-71, 2013.

R. A. De-boer, L. B. Daniels, A. S. Maisel, and J. L. Januzzi, State of the Art: Newer biomarkers in heart failure, Eur J Heart Fail, vol.17, pp.559-69, 2015.

H. Zhou, J. Ni, and Y. Yuan, Soluble ST2 may possess special superiority as a risk predictor in heart failure patients, Int J Cardiol, vol.186, pp.146-153, 2015.

O. F. Abouezzeddine, P. M. Mckie, and S. M. Dunlay, Suppression of Tumorigenicity 2 in Heart Failure With Preserved Ejection Fraction, J Am Heart Assoc, vol.6, 2017.

E. Donal, L. H. Lund, and C. Linde, Rationale and design of the Karolinska-Rennes (KaRen) prospective study of dyssynchrony in heart failure with preserved ejection fraction, Eur J Heart Fail, vol.11, pp.198-204, 2009.
URL : https://hal.archives-ouvertes.fr/hal-00911681

R. P. Kelly, C. T. Ting, and T. M. Yang, Effective arterial elastance as index of arterial vascular load in humans, Circulation, vol.86, pp.513-534, 1992.

C. H. Chen, B. Fetics, and E. Nevo, Noninvasive single-beat determination of left ventricular end-systolic elastance in humans, J Am Coll Cardiol, vol.38, pp.2028-2062, 2001.

D. Chemla, J. L. Hebert, and C. Coirault, Total arterial compliance estimated by stroke volume-to-aortic pulse pressure ratio in humans, Am J Physiol, vol.274, pp.500-505, 1998.

S. R. Ommen, R. A. Nishimura, and C. P. Appleton, Clinical utility of Doppler echocardiography and tissue Doppler imaging in the estimation of left ventricular filling pressures: A comparative simultaneous Doppler-catheterization study, Circulation, vol.102, pp.1788-94, 2000.

S. Klotz, I. Hay, and M. L. Dickstein, Single-beat estimation of end-diastolic pressurevolume relationship: a novel method with potential for noninvasive application, Am J Physiol Heart Circ Physiol, vol.291, pp.403-415, 2006.

G. Dahlberg, Statistical methods for medical and biological students

. Allen-&-unwin-ltd, , 1940.

S. S. Kuppahally, N. Akoum, and N. S. Burgon, Left atrial strain and strain rate in patients with paroxysmal and persistent atrial fibrillation: relationship to left atrial structural remodeling detected by delayed-enhancement MRI, Circ Cardiovasc Imaging, vol.3, issue.23, pp.231-240, 2010.

M. Cameli, M. Lisi, and F. M. Righini, Usefulness of atrial deformation analysis to predict left atrial fibrosis and endocardial thickness in patients undergoing mitral valve operations for severe mitral regurgitation secondary to mitral valve prolapse, Am J Cardiol, vol.111, pp.595-601, 2013.

M. R. Zile, P. S. Jhund, and C. F. Baicu, Plasma Biomarkers Reflecting Profibrotic Processes in Heart Failure With a Preserved Ejection Fraction: Data From the Prospective Comparison of ARNI With ARB on Management of Heart Failure With Preserved Ejection Fraction Study, Circ Heart Fail, vol.9, 2016.

J. Bartunek, L. Delrue, and F. Van-durme, Nonmyocardial production of ST2 protein in human hypertrophy and failure is related to diastolic load, J Am Coll Cardiol, vol.52, pp.2166-74, 2008.

C. P. Appleton and S. J. Kovacs, The role of left atrial function in diastolic heart failure, Circ Cardiovasc Imaging, vol.2, pp.6-9, 2009.

N. Hanna, S. Cardin, T. K. Leung, and S. Nattel, Differences in atrial versus ventricular remodeling in dogs with ventricular tachypacing-induced congestive heart failure, Cardiovasc Res, vol.63, pp.236-280, 2004.

Y. Sun, F. J. Ramires, and K. T. Weber, Fibrosis of atria and great vessels in response to angiotensin II or aldosterone infusion, Cardiovasc Res, vol.35, pp.138-185, 1997.

L. Tourneau, T. Richardson, M. Juthier, and F. , Echocardiography predictors and prognostic value of pulmonary artery systolic pressure in chronic organic mitral regurgitation, Heart, vol.96, pp.1311-1318, 2010.

M. Kawaguchi, I. Hay, B. Fetics, and D. A. Kass, Combined ventricular systolic and arterial stiffening in patients with heart failure and preserved ejection fraction: implications for systolic and diastolic reserve limitations, Circulation, vol.107, pp.714-734, 2003.

A. B. Santos, G. Q. Roca, and B. Claggett, Prognostic Relevance of Left Atrial Dysfunction in Heart Failure With Preserved Ejection Fraction, Circ Heart Fail, vol.9, p.2763, 2016.

. Nt-probnp, , vol.3, p.2335

, ST2 (ng/mL) 32 (Q1:24, vol.3, p.48

, Hemoglobin

, White blood cell count, vol.9, issue.10, p.9

N. Biochemical,

, Table 2. Cardiac and vascular geometric and functional measures in the two groups stratified according to LA-GS. BMI, body mass index; SBP, systolic blood pressure, DBP

L. V. ,

, EDVi, end-diastolic volume index

, ESVi, end-systolic volume index

. Lvmi, LV mass index

, EF, ejection fraction; LV-GLS, LV global longitudinal strain

, SVi, stroke volume index

. Ees,

E. , ratio between the early diastolic inflow velocity (E) to the inflow velocity due to atrial contraction (A)

, e' mean, mean value of early myocardial velocity in LV basal septal and lateral wall

, non-invasive; tau, time constant of LV isovolumic relaxation; ?, diastolic stiffness constant describing the steepness of the EDPVR curve

E. Edv,

. Ea,

S. Svri, ;. Vascular-resistance-index, and . La, left atrial end-systolic volume; LA-GS, left atrial global longitudinal strain; LA EF, left atrial ejection fraction

, TAPSE, tricuspid annular plane systolic excursion; NT-proBNP, Nterminal pro-brain natriuretic peptide

, ST2, soluble suppression of tumorigenicity-2 receptor; eGFR, estimated glomerular filtration rate; NS, non-significant (p ? 0.05). Data are provided as mean ± SD followed by patient number in brackets; or median values followed by 1st and