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Journal articles
Pregnancy Outcomes after ZIKV Infection in French Territories in the Americas
Bruno Hoen
1, 2, 3
Bruno Schaub
4
Anna L Funk
5
Vanessa Ardillon
6
Manon Boullard
2
André Cabié
2
Caroline Callier
2
Gabriel Carles
7
Sylvie Cassadou
6
Raymond Césaire
8
Maylis Douine
2
Cécile Herrmann-Storck
1
Philippe Kadhel
1
Cédric Laouénan
9
Yoann Madec
5
Alice Monthieux
10
Mathieu Nacher
2
Fatiha Najioullah
8
Dominique Rousset
11
Catherine Ryan
1
Kinda Schepers
12
Sofia Stegmann-Planchard
13
Benoît Tressières
2
Jean-Luc Voluménie
4
Samson Yassinguezo
14
Eustase Janky
1
Arnaud Fontanet
5, 15, 16
Bruno Hoen 1, 2, 3
Author IdHAL : bruno-hoen ORCID : https://orcid.org/0000-0003-3070-3017
Bruno Schaub 4
Author
Anna L Funk 5
Author
Vanessa Ardillon 6
Author
Manon Boullard 2
Author
André Cabié 2
Author IdHAL : andre-cabie ORCID : https://orcid.org/0000-0003-0117-3061
Caroline Callier 2
Author
Gabriel Carles 7
Author
Sylvie Cassadou 6
Author
Raymond Césaire 8
Author
Maylis Douine 2
Author
Cécile Herrmann-Storck 1
Author
Philippe Kadhel 1
Author
Cédric Laouénan 9
Author
Yoann Madec 5
Author IdHAL : yoann-madec ORCID : https://orcid.org/0000-0002-6201-1261
Alice Monthieux 10
Author
Mathieu Nacher 2
Author IdHAL : mathieu-nacher ORCID : https://orcid.org/0000-0001-9397-3204
Fatiha Najioullah 8
Author
Dominique Rousset 11
Author IdHAL : dominique-rousset211 ORCID : https://orcid.org/0000-0002-1473-3147
Catherine Ryan 1
Author
Kinda Schepers 12
Author
Sofia Stegmann-Planchard 13
Author
Benoît Tressières 2
Author
Jean-Luc Voluménie 4
Author
1
CHU Pointe-à-Pitre/Abymes [Guadeloupe] (Route de Chauvel - BP 465 - 97159 Pointe-à-Pitre cedex - France)
2
CIC - Antilles Guyane - Centre d'investigation clinique Antilles-Guyane (Cayenne - French Guiana)
- INSERM - Institut National de la Santé et de la Recherche Médicale : CIE802 (101, rue de Tolbiac, 75013 Paris - France)
- CHU de la Martinique [Fort de France] (CS 90632 – 97261 Fort de France Cedex Martinique - Martinique)
- CHU Pointe-à-Pitre/Abymes [Guadeloupe] (Route de Chauvel - BP 465 - 97159 Pointe-à-Pitre cedex - France)
- Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française] (Av des flamboyants, Cayenne 97306 - French Guiana)
3
UAG - Université des Antilles et de la Guyane (Fouillole - BP 250 - 97157 Pointe-à-Pitre - Guadeloupe)
4
MFME [Fort de France] - Maison de la Femme de la Mère et de l'Enfant [CHU de la Martinique] (CS 90632 – 97261 Fort de France Cedex - Martinique)
- CHU de la Martinique [Fort de France] (CS 90632 – 97261 Fort de France Cedex Martinique - Martinique)
5
Epidémiologie des Maladies Emergentes - Emerging Diseases Epidemiology (Département Infection et Epidémiologie, 25-28 rue du Docteur Roux, F-75724 Paris Cedex 15 - France)
- PACRI - Pasteur-Cnam risques infectieux et émergents (Paris - France)
- CNAM - Conservatoire National des Arts et Métiers [CNAM] (France)
- Institut Pasteur [Paris] (25-28, rue du docteur Roux, 75724 Paris cedex 15 - France)
6
Santé publique France - French National Public Health Agency (Santé publique France (siège social)
12, rue du Val d'Osne 94415 Saint-Maurice cedex - France)
7
Centre Hospitalier de l'Ouest Guyanais Franck Joly [Saint-Laurent-du-Maroni, Guyane Française] (16 avenue du Général de Gaulle, 97393 Saint-Laurent-du-Maroni. - French Guiana)
8
CHU de la Martinique [Fort de France] (CS 90632 – 97261 Fort de France Cedex
Martinique - Martinique)
9
IAME (UMR_S_1137 / U1137) - Infection, Anti-microbiens, Modélisation, Evolution (Faculté de médecine Paris Diderot Paris 7 - site Bichat - 16 rue Henri Huchard 75890 Paris Cedex 18 - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U1137 (101, rue de Tolbiac, 75013 Paris - France)
- UP13 - Université Paris 13 (France)
- UPD7 - Université Paris Diderot - Paris 7 : UMR_S_1137 (5 rue Thomas-Mann - 75205 Paris cedex 13 - France)
- USPC - Université Sorbonne Paris Cité (Université Sorbonne Paris Cité | 100-104, avenue de France | 75013 Paris - France)
10
UAG UFR SM - Université des Antilles et de la Guyane - UFR des sciences médicales (Faculté de Médecine Hyacinthe Bastaraud - Campus de Fouillole - BP 145 - 97154 Pointe à Pitre Cedex - Guadeloupe)
- UAG - Université des Antilles et de la Guyane (Fouillole - BP 250 - 97157 Pointe-à-Pitre - Guadeloupe)
11
Institut Pasteur de la Guyane (23 Avenue Pasteur BP 6010 - 97306 Cayenne Cedex - French Guiana)
- RIIP - Réseau International des Instituts Pasteur (25, rue du Dr Roux 75724 Paris Cedex 15 - France)
12
MAITC EA 4537 - Maladies infectieuses et tropicales dans la Caraïbe (Laboratoire de Virologie-Immunologie, CHU de Fort-de-France, BP632, 97261 Fort-de-France cedex - France)
- CHU Pointe-à-Pitre/Abymes [Guadeloupe] (Route de Chauvel - BP 465 - 97159 Pointe-à-Pitre cedex - France)
- UA - Université des Antilles : EA 4537 (Université des Antilles | Fouillole - BP 250 - 97157 Pointe-à-Pitre - France)
- CHU de la Martinique [Fort de France] (CS 90632 – 97261 Fort de France Cedex Martinique - Martinique)
13
Centre Hospitalier Louis Constant Fleming (Saint Martin)
14
Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française] (Av des flamboyants, Cayenne 97306 - French Guiana)
15
CGH - Center for Global Health (25-28, rue du Docteur Roux
75724 Paris Cedex 15 - France)
- Institut Pasteur [Paris] (25-28, rue du docteur Roux, 75724 Paris cedex 15 - France)
- RIIP - Réseau International des Instituts Pasteur (25, rue du Dr Roux 75724 Paris Cedex 15 - France)
Abstract : BACKGROUND:
The risk of congenital neurologic defects related to Zika virus (ZIKV) infection has ranged from 6 to 42% in various reports. The aim of this study was to estimate this risk among pregnant women with symptomatic ZIKV infection in French territories in the Americas.
METHODS:
From March 2016 through November 2016, we enrolled in this prospective cohort study pregnant women with symptomatic ZIKV infection that was confirmed by polymerase-chain-reaction (PCR) assay. The analysis included all data collected up to April 27, 2017, the date of the last delivery in the cohort.
RESULTS:
Among the 555 fetuses and infants in the 546 pregnancies included in the analysis, 28 (5.0%) were not carried to term or were stillborn, and 527 were born alive. Neurologic and ocular defects possibly associated with ZIKV infection were seen in 39 fetuses and infants (7.0%; 95% confidence interval, 5.0 to 9.5); of these, 10 were not carried to term because of termination of pregnancy for medical reasons, 1 was stillborn, and 28 were live-born. Microcephaly (defined as head circumference more than 2 SD below the mean for sex and gestational age) was detected in 32 fetuses and infants (5.8%), of whom 9 (1.6%) had severe microcephaly (more than 3 SD below the mean). Neurologic and ocular defects were more common when ZIKV infection occurred during the first trimester (24 of 189 fetuses and infants [12.7%]) than when it occurred during the second trimester (9 of 252 [3.6%]) or third trimester (6 of 114 [5.3%]) (P=0.001).
CONCLUSIONS:
Among pregnant women with symptomatic, PCR-confirmed ZIKV infection, birth defects possibly associated with ZIKV infection were present in 7% of fetuses and infants. Defects occurred more frequently in fetuses and infants whose mothers had been infected early in pregnancy. Longer-term follow-up of infants is required to assess any manifestations not detected at birth. (Funded by the French Ministry of Health and others; ClinicalTrials.gov number, NCT02916732 .).
Document type :
Journal articles
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https://hal-univ-rennes1.archives-ouvertes.fr/hal-01744446
Contributor : Laurent Jonchère <>
Submitted on : Monday, April 16, 2018 - 2:33:21 PM
Last modification on : Thursday, February 25, 2021 - 2:32:21 PM
Contributor : Laurent Jonchère <>
Submitted on : Monday, April 16, 2018 - 2:33:21 PM
Last modification on : Thursday, February 25, 2021 - 2:32:21 PM
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Identifiers
- HAL Id : hal-01744446, version 1
- DOI : 10.1056/NEJMoa1709481
- PUBMED : 29539287
Collections
CNAM | UNIV-AG | PASTEUR | RIIP | RIIP_GUYANE | UNIV-PARIS7 | UNIV-PARIS13 | USPC | UNIV-HESAM | IAME | SORBONNE-PARIS-NORD | MAITC | UNIV-PARIS | UP-SANTE | UNIV-RENNES | UNIV-RENNES1 | INSERM | POLITIQUES-PUBLIQUES
Citation
Bruno Hoen, Bruno Schaub, Anna L Funk, Vanessa Ardillon, Manon Boullard, et al.. Pregnancy Outcomes after ZIKV Infection in French Territories in the Americas. New England Journal of Medicine, Massachusetts Medical Society, 2018, 378 (11), pp.985-994. ⟨10.1056/NEJMoa1709481⟩. ⟨hal-01744446⟩
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