Bacterial adaptation to antibiotics through regulatory RNAs - Archive ouverte HAL Access content directly
Journal Articles Antimicrobial Agents and Chemotherapy Year : 2018

Bacterial adaptation to antibiotics through regulatory RNAs


The extensive use of antibiotics has resulted in a situation where multidrug-resistant pathogens have become a severe menace to human health worldwide. A deeper understanding of the principles used by pathogens to adapt to, respond to, and resist antibiotics would pave the road to the discovery of drugs with novel mechanisms. For bacteria, antibiotics represent clinically relevant stresses that induce protective responses. The recent implication of regulatory RNAs (small RNAs [sRNAs]) in antibiotic response and resistance in several bacterial pathogens suggests that they should be considered innovative drug targets. This minireview discusses sRNA-mediated mechanisms exploited by bacterial pathogens to fight against antibiotics. A critical discussion of the newest findings in the field is provided, with emphasis on the implication of sRNAs in major mechanisms leading to antibiotic resistance, including drug uptake, active drug efflux, drug target modifications, biofilms, cell walls, and lipopolysaccharide (LPS) biosynthesis. Of interest is the lack of knowledge about sRNAs implicated in Gram-positive compared to Gram-negative bacterial resistance.
Fichier principal
Vignette du fichier
Felden - Bacterial adaptation to antibiotics.pdf (2.13 Mo) Télécharger le fichier
Origin : Files produced by the author(s)

Dates and versions

hal-01764887 , version 1 (23-08-2018)



Brice Felden, Vincent Cattoir. Bacterial adaptation to antibiotics through regulatory RNAs. Antimicrobial Agents and Chemotherapy, 2018, 62 (5), pp.e02503-17. ⟨10.1128/AAC.02503-17⟩. ⟨hal-01764887⟩
113 View
101 Download



Gmail Facebook Twitter LinkedIn More