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Journal articles
Dual IRE1 RNase functions dictate glioblastoma development
Stéphanie Lhomond
1
Tony Avril
2
Nicolas Dejeans
1
Konstantinos Voutetakis
3
Dimitrios Doultsinos
2
Mari Mcmahon
2
Raphael Pineau
2
Joanna Obacz
2
Olga Papadodima
3
Florence Jouan
2
Heloise Bourien
2
Marianthi Logotheti
3
Gwenaele Jegou
2
Nestor Pallares-Lupon
1
Kathleen Schmit
1
Pierre-Jean Le Reste
2
Amandine Etcheverry
4
Jean Mosser
4
Kim Barroso
2
Elodie Vauléon
2
Marion Maurel
2
Afshin Samali
5
John B. Patterson
Olivier Pluquet
6
Claudio Hetz
7
Véronique Quillien
2
Aristotelis Chatziioannou
3
Eric Chevet
2, *
*
Corresponding author
Stéphanie Lhomond 1
Author
Tony Avril 2
Author
Nicolas Dejeans 1
Author
Konstantinos Voutetakis 3
Author
Olga Papadodima 3
Author
Florence Jouan 2
Author
Heloise Bourien 2
Author
Marianthi Logotheti 3
Author
Gwenaele Jegou 2
Author
Nestor Pallares-Lupon 1
Author
Kathleen Schmit 1
Author
Pierre-Jean Le Reste 2
Author
Amandine Etcheverry 4
Author IdHAL : amandine-etcheverry ORCID : https://orcid.org/0000-0003-4092-8308
Jean Mosser 4
Author
Kim Barroso 2
Author
Elodie Vauléon 2
Author
Claudio Hetz 7
Author
Véronique Quillien 2
Author
Aristotelis Chatziioannou 3
Author
Eric Chevet 2
Correspondent author
1
UB - Université de Bordeaux (35, place Pey Berland - 33076 Bordeaux - France)
2
COSS - Chemistry, Oncogenesis, Stress and Signaling (Université de Rennes1 - CLCC Eugène Marquis, Rue de la Bataille Flandres Dunkerque, Bat D, 35042 Rennes - France)
- UR1 - Université de Rennes 1 (2 rue du Thabor - CS 46510 - 35065 Rennes cedex - France)
- UNIV-RENNES - Université de Rennes (France)
- CRLCC - CRLCC Eugène Marquis (Avenue Bataille Flandres-Dunkerque 35042 RENNES CEDEX - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U1242 (101, rue de Tolbiac, 75013 Paris - France)
3
Theoretical and Physical Chemistry Institute NHRF (Theoretical and Physical Chemistry Institute, National Hellenic Research Foundation, Vasileos Constantinou 48, 116 35 Athens, Greece - Greece)
4
IGDR - Institut de Génétique et Développement de Rennes (Faculté de Médecine - CS 34317 2 Av du Professeur Léon Bernard 35043 Rennes Cedex - France)
- UR1 - Université de Rennes 1 (2 rue du Thabor - CS 46510 - 35065 Rennes cedex - France)
- UNIV-RENNES - Université de Rennes (France)
- CNRS - Centre National de la Recherche Scientifique : UMR6290 (France)
- Biosit : Biologie - Santé - Innovation Technologique - Structure Fédérative de Recherche en Biologie et Santé de Rennes (Université Rennes 1 - Campus Santé Villejean - 2, avenue Professeur Léon Bernard 35043 Rennes cedex - France)
6
M3T - Mécanismes de la Tumorigénèse et Thérapies Ciblées (M3T) - UMR 8161 (France)
- Institut Pasteur de Lille (1 Rue du Professeur Calmette - Lille Cedex - 59019 - France)
- RIIP - Réseau International des Instituts Pasteur (25, rue du Dr Roux 75724 Paris Cedex 15 - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale (101, rue de Tolbiac, 75013 Paris - France)
- Université de Lille (Lille - France)
- CNRS - Centre National de la Recherche Scientifique : 8161 (France)
7
USACH - Universidad de Santiago de Chile [Santiago] (Universidad de Santiago de Chile. Avenida Libertador Bernardo O'Higgins nº 3363. Estación Central. Santiago. Chile - Chile)
Abstract : Proteostasis imbalance is emerging as a major hallmark of cancer, driving tumor aggressiveness. Evidence suggests that the endoplasmic reticulum (ER), a major site for protein folding and quality control, plays a critical role in cancer development. This concept is valid in glioblastoma multiform (GBM), the most lethal primary brain cancer with no effective treatment. We previously demonstrated that the ER stress sensor IRE1 alpha (referred to as IRE1) contributes to GBM progression, through XBP1 mRNA splicing and regulated IRE1-dependent decay (RIDD) of RNA. Here, we first demonstrated IRE1 signaling significance to human GBM and defined specific IRE1-dependent gene expression signatures that were confronted to human GBM transcriptomes. This approach allowed us to demonstrate the antagonistic roles of XBP1 mRNA splicing and RIDD on tumor outcomes, mainly through selective remodeling of the tumor stroma. This study provides the first demonstration of a dual role of IRE1 downstream signaling in cancer and opens a new therapeutic window to abrogate tumor progression.
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Journal articles
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Complete list of metadata
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01777737
Contributor : Laurent Jonchère Connect in order to contact the contributor
Submitted on : Wednesday, April 25, 2018 - 9:42:32 AM
Last modification on : Wednesday, February 24, 2021 - 11:48:04 AM
Long-term archiving on: : Wednesday, September 19, 2018 - 8:18:16 PM
Contributor : Laurent Jonchère Connect in order to contact the contributor
Submitted on : Wednesday, April 25, 2018 - 9:42:32 AM
Last modification on : Wednesday, February 24, 2021 - 11:48:04 AM
Long-term archiving on: : Wednesday, September 19, 2018 - 8:18:16 PM
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EMMM-10-e7929.pdf
Publisher files allowed on an open archive
Licence
Distributed under a Creative Commons Attribution 4.0 International License
Identifiers
- HAL Id : hal-01777737, version 1
- DOI : 10.15252/emmm.201707929
- PUBMED : 29311133
Collections
UNIV-RENNES1 | OSS | CNRS | RIIP | RIIP_LILLE | MARQUIS | IGDR | FNCLCC | BIOSIT | UR1-UFR-SVE | UNIV-RENNES | UNIV-LILLE
Citation
Stéphanie Lhomond, Tony Avril, Nicolas Dejeans, Konstantinos Voutetakis, Dimitrios Doultsinos, et al.. Dual IRE1 RNase functions dictate glioblastoma development. EMBO Molecular Medicine, Wiley Open Access, 2018, 10 (3), pp.e7929. ⟨10.15252/emmm.201707929⟩. ⟨hal-01777737⟩
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