Effects of Hexachlorophene, a Chemical Accumulating in Adipose Tissue, on Mouse and Human Mesenchymal Stem Cells

Monika Lesniak , Robert Zdanowski , Milena Suska , Aleksandra Brewczynska , Wanda Stankiewicz , Malgorzata Kloc (1) , Jacek Z. Kubiak (2) , Slawomir Lewicki

1 The University of Texas M.D. Anderson Cancer Center [Houston]
2 IGDR - Institut de Génétique et Développement de Rennes

The hexachlorophene (HCP) is a highly lipophilic chlorinated bisphenol present in hygienic and dermatological products. The HCP accumulates preferentially in adipose tissue that is a privileged source of mesenchymal stem cells (MSCs). The evaluation of the potential effects of HCP on MSCs is important for their medical application. Here we examined the effects of HCP on murine adipose tissue-derived stem cells (ADSCs) and human umbilical cord-derived stem cells (UCSCs) in cell culture. We found that 10(-4) and 10(-5) M HCP inhibits proliferation, osteogenesis and increases apoptosis of ADSCs and UCSCs. While the effect of HCP on proliferation and differentiation potential of these two cell lines was similar, the UCSCs appeared much more resistant to HCP-induced apoptosis than ADSCs. These results suggest that the adipose tissue-derived ADSCs have higher sensitive for HCP than umbilical cord-derived UCSCs and indicate that the umbilical cord can be a preferable source of MSCs for prospective medical applications in the future.

Keywords: Mesenchymal stem cells; Hexachlorophene; Adipose tissue; Apoptosis; Unbilical cord

Domains: Life Sciences [q-bio]

Monika Lesniak, Robert Zdanowski, Milena Suska, Aleksandra Brewczynska, Wanda Stankiewicz, et al.. Effects of Hexachlorophene, a Chemical Accumulating in Adipose Tissue, on Mouse and Human Mesenchymal Stem Cells. Tissue Engineering and Regenerative Medicine, 2018, 15 (2), pp.211-222. ⟨10.1007/s13770-017-0103-9⟩. ⟨hal-01778142⟩