Skip to Main content Skip to Navigation
Journal articles

Effects of Hexachlorophene, a Chemical Accumulating in Adipose Tissue, on Mouse and Human Mesenchymal Stem Cells

Abstract : The hexachlorophene (HCP) is a highly lipophilic chlorinated bisphenol present in hygienic and dermatological products. The HCP accumulates preferentially in adipose tissue that is a privileged source of mesenchymal stem cells (MSCs). The evaluation of the potential effects of HCP on MSCs is important for their medical application. Here we examined the effects of HCP on murine adipose tissue-derived stem cells (ADSCs) and human umbilical cord-derived stem cells (UCSCs) in cell culture. We found that 10(-4) and 10(-5) M HCP inhibits proliferation, osteogenesis and increases apoptosis of ADSCs and UCSCs. While the effect of HCP on proliferation and differentiation potential of these two cell lines was similar, the UCSCs appeared much more resistant to HCP-induced apoptosis than ADSCs. These results suggest that the adipose tissue-derived ADSCs have higher sensitive for HCP than umbilical cord-derived UCSCs and indicate that the umbilical cord can be a preferable source of MSCs for prospective medical applications in the future.
Document type :
Journal articles
Complete list of metadatas

https://hal-univ-rennes1.archives-ouvertes.fr/hal-01778142
Contributor : Laurent Jonchère <>
Submitted on : Wednesday, April 25, 2018 - 2:27:41 PM
Last modification on : Sunday, October 25, 2020 - 6:45:22 AM
Long-term archiving on: : Tuesday, September 25, 2018 - 6:26:14 PM

File

s13770-017-0103-9.pdf
Publisher files allowed on an open archive

Licence


Distributed under a Creative Commons Attribution 4.0 International License

Identifiers

Citation

Monika Lesniak, Robert Zdanowski, Milena Suska, Aleksandra Brewczynska, Wanda Stankiewicz, et al.. Effects of Hexachlorophene, a Chemical Accumulating in Adipose Tissue, on Mouse and Human Mesenchymal Stem Cells. Tissue Engineering and Regenerative Medicine, Springer Verlag, 2018, 15 (2), pp.211-222. ⟨10.1007/s13770-017-0103-9⟩. ⟨hal-01778142⟩

Share

Metrics

Record views

132

Files downloads

137