Analysis of Hemodynamic Changes and Bold Signals of Sickle Cell Disease Patients during Desaturation

Julie Coloigner (1) , Chau Vu (2) , Matt Borzage (2) , Adam Bush (3) , Natasha Lepore (4) , Thomas D. Coates (2) , John Wood (2)

1 LTSI - Laboratoire Traitement du Signal et de l'Image
2 Children’s Hospital Los Angeles [Los Angeles]
3 Department of Cardiology
4 USC - University of Southern California

Using near­infrared spectroscopy (NIRS), previous studies have shown that sickle­cell disease (SCD) patients have low cerebral oxygen saturation values. Moreover, the hemoglobin S in sickle cell disease has impaired oxygen carrying capacity. Here, we propose to investigate the effect of induced desaturation on the SCD brain. In particular, we analyzed the falling functional magnetic resonance imaging (fMRI) response during hypoxia, which results from local concentration changes in paramagnetic deoxy­hemoglobin (DHB). Moreover, we also explore the near­infrared spectroscopy (NIRS) changes in oxygenated and deoxygenated hemoglobin from the human prefrontal cortex.

Domaines: Traitement du signal et de l'image [eess.SP]

Julie Coloigner, Chau Vu, Matt Borzage, Adam Bush, Natasha Lepore, et al.. Analysis of Hemodynamic Changes and Bold Signals of Sickle Cell Disease Patients during Desaturation. 57th American Society of Hematology (ASH) conference, 2015, Orlando, United States. ⟨hal-01792249⟩