Low-frequency fluctuation amplitude analysis of resting-state fMRI for sickle cell disease patients - Université de Rennes Accéder directement au contenu
Communication Dans Un Congrès Année : 2015

Low-frequency fluctuation amplitude analysis of resting-state fMRI for sickle cell disease patients

Résumé

Sickle cell disease may result in neurological damage and strokes, leading to morbidity and mortality. The inability of conventional magnetic resonance imaging to predict impending stroke underlies the need for other neuroimaging markers risk. In this study, we analyzed neuronal processes at resting state and more particularly how this disease affects the default mode network. The amplitude of low frequency fluctuations was used to reflect areas of spontaneous BOLD signal across brain regions. We compared the activations of sickle cell disease patients to a control group with variance analysis and t-test. Significant differences in different parts among the two groups were observed, especially in the default mode network areas and cortical regions near large cerebral arteries. These findings suggest that sickle cell disease can cause some activation modifications near vessels, and these changes could be used a biomarker of the malady.
Fichier principal
Vignette du fichier
Coloigner_SIPAIM_2015.pdf (571.63 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)
Loading...

Dates et versions

hal-01792258 , version 1 (15-05-2018)

Identifiants

  • HAL Id : hal-01792258 , version 1

Citer

Julie Coloigner, Yeun Kim, Adam Bush, Matt Borzage, Vidya Rajagopalan, et al.. Low-frequency fluctuation amplitude analysis of resting-state fMRI for sickle cell disease patients. 11th International Symposium on Medical Information Processing and Analysis, 2015, Cuenca-Ecuador, Ecuador. ⟨hal-01792258⟩
102 Consultations
180 Téléchargements

Partager

Gmail Facebook X LinkedIn More