Manganese catalyzed reductive amination of aldehydes using hydrogen as a reductant

Abstract : A one-pot two-step procedure was developed for the alkylation of amines via reductive amination of aldehydes using molecular dihydrogen as a reductant in the presence of a manganese pyridinyl-phosphine complex as a pre-catalyst. After the initial condensation step, the reduction of imines formed in situ is performed under mild conditions (50-100 degrees C) with 2 mol% of catalyst and 5 mol% of tBuOK under 50 bar of hydrogen. Excellent yields (>90%) were obtained for a large combination of aldehydes and amines (40 examples), including aliphatic aldehydes and amino-alcohols.
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Duo Wei, Antoine Bruneau-Voisine, Dmitry A. Valyaev, Noel Lugan, Jean-Baptiste Sortais. Manganese catalyzed reductive amination of aldehydes using hydrogen as a reductant. Chemical Communications, Royal Society of Chemistry, 2018, 54 (34), pp.4302-4305. ⟨10.1039/C8CC01787E⟩. ⟨hal-01807069⟩

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