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Journal articles
Selectivity Modulation and Structure of alpha/aza-beta(3) Cyclic Antimicrobial Peptides
Abstract : Potent and selective antimicrobial cyclic pseudopeptides (ACPPs) mixing α- and aza-β -amino acids were developed. Cyclopseudopeptide sequences were designed to investigate the impact of some intrinsic molecular parameters on their biological activities. Fine changes in the nature of the side chains strongly modulated the selectivity of the ACPPs with regard to hemolysis versus antimicrobial activity. The conformational preference of such compounds in various media was extensively studied, and the typical structure of cyclic α/aza-β -pseudopeptides is described for the first time. Interestingly, such scaffolds are stabilized by successive inverse γ- and N-N turns (hydrazino turns), a unique feature due to the aza-β residues. The α-amino acid side chains form a cluster on one face of the ring, while the aza-β -amino acid side chains are projected around the ring in the equatorial orientation. Such structural data are particularly valuable to fine-tune the bioactivity of these ACPPs by a structure-based approach.
Cited literature [68 references]
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01807077
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Submitted on : Tuesday, June 19, 2018 - 10:11:23 AM
Last modification on : Tuesday, January 4, 2022 - 4:26:15 AM
Long-term archiving on: : Tuesday, September 25, 2018 - 12:22:12 AM
Contributor : Laurent Jonchère Connect in order to contact the contributor
Submitted on : Tuesday, June 19, 2018 - 10:11:23 AM
Last modification on : Tuesday, January 4, 2022 - 4:26:15 AM
Long-term archiving on: : Tuesday, September 25, 2018 - 12:22:12 AM
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