H. B. El-serag and K. L. Rudolph, Hepatocellular carcinoma: epidemiology and molecular carcinogenesis, Gastroenterology, vol.132, issue.7, pp.2557-2576, 2007.

S. Rebouissou, A. Franconi, J. Calderaro, E. Letouze, S. Imbeaud et al.,

, Genotype-phenotype correlation of CTNNB1 mutations reveals different b-catenin activity associated with liver tumor progression, Hepatology, vol.64, issue.6, pp.2047-2061, 2016.

J. Zucman-rossi, A. Villanueva, J. C. Nault, and J. M. Llovet, Genetic Landscape and Biomarkers of Hepatocellular Carcinoma, Gastroenterology, vol.149, issue.5, pp.1226-1239, 2015.

K. Schulze, S. Imbeaud, E. Letouze, L. B. Alexandrov, J. Calderaro et al., Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets, Nat Genet, vol.47, issue.5, pp.505-511, 2015.
URL : https://hal.archives-ouvertes.fr/inserm-01159736

A. Fujimoto, M. Furuta, Y. Totoki, T. Tsunoda, M. Kato et al., Wholegenome mutational landscape and characterization of noncoding and structural mutations in liver cancer, Nat Genet, vol.48, issue.5, pp.500-509, 2016.

J. Calderaro, G. Couchy, S. Imbeaud, G. Amaddeo, E. Letouzé et al.,

, Histological Subtypes of Hepatocellular Carcinoma Are Related To Gene Mutations and Molecular Tumour Classification, J Hepatol, vol.67, issue.4, pp.727-738, 2017.

E. Lee, A. Salic, R. Kruger, R. Heinrich, and M. W. Kirschner, The roles of APC and 8

S. Colnot, T. Decaens, M. Niwa-kawakita, C. Godard, G. Hamard et al.,

, Liver-targeted disruption of Apc in mice activates beta-catenin signaling and leads to hepatocellular carcinomas, Proc Natl Acad Sci U S A, vol.101, issue.49, pp.17216-17221, 2004.

S. Satoh, Y. Daigo, Y. Furukawa, T. Kato, N. Miwa et al.,

, mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1, Nat Genet, vol.24, issue.3, pp.245-250, 2000.

J. Zucman-rossi, S. Benhamouche, C. Godard, S. Boyault, and G. Grimber,

C. Balabaud, Differential effects of inactivated Axin1 and activated beta-catenin mutations in human hepatocellular carcinomas, Oncogene, vol.26, issue.5, pp.774-780, 2007.

S. Boyault, D. S. Rickman, A. De-reynies, C. Balabaud, S. Rebouissou et al., Transcriptome classification of HCC is related to gene alterations and to new therapeutic targets, Hepatology, vol.45, issue.1, pp.42-52, 2007.
URL : https://hal.archives-ouvertes.fr/inserm-00130313

G. J. Feng, W. Cotta, X. Q. Wei, O. Poetz, R. Evans et al., Conditional disruption of Axin1 leads to development of liver tumors in mice, Gastroenterology, vol.143, issue.6, pp.1650-1659, 2012.

A. Cadoret, C. Ovejero, B. Terris, E. Souil, L. Levy et al., New targets of b-catenin signaling in the liver are involved in the glutamine metabolism

, Oncogene, vol.21, issue.54, pp.8293-301, 2002.

C. A. Renard, C. Labalette, C. Armengol, D. Cougot, Y. Wei et al., Tbx3 is a downstream target of the Wnt/beta-catenin pathway and a critical mediator of betacatenin survival functions in liver cancer, Cancer Res, vol.67, issue.3, pp.901-911, 2007.

C. Ovejero, C. Cavard, A. Perianin, T. Hakvoort, J. Vermeulen et al.,

S. Benhamouche, T. Decaens, C. Godard, R. Chambery, D. S. Rickman et al.,

C. , Apc tumor suppressor gene is the "zonation-keeper" of mouse liver, Dev Cell, vol.10, issue.6, pp.759-70, 2006.

J. Wang, J. S. Park, Y. Wei, M. Rajurkar, J. L. Cotton et al., TRIB2 acts downstream of Wnt/TCF in liver cancer cells to regulate YAP and C/EBPa function

, Mol Cell, vol.51, issue.2, pp.211-236, 2013.

C. Pilati, E. Letouzé, J. C. Nault, S. Imbeaud, A. Boulai et al., Genomic profiling of hepatocellular adenomas reveals recurrent FRK-activating mutations and the mechanisms of malignant transformation, Cancer Cell, vol.25, issue.4, pp.428-469, 2014.

C. Guichard, G. Amaddeo, S. Imbeaud, Y. Ladeiro, L. Pelletier et al.,

, Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma, Nat Genet, vol.44, issue.6, pp.694-702, 2012.

V. Audard, G. Grimber, C. Elie, B. Radenin, A. Audebourg et al.,

, Cholestasis is a marker for hepatocellular carcinomas displaying beta-catenin mutations, J Pathol, vol.212, issue.3, pp.345-52, 2007.

Y. Hoshida, S. M. Nijman, M. Kobayashi, J. A. Chan, J. P. Brunet et al.,

, Integrative transcriptome analysis reveals common molecular subclasses of human hepatocellular carcinoma, Cancer Res, vol.69, issue.18, pp.7385-7392, 2009.

D. Y. Chiang, A. Villanueva, Y. Hoshida, J. Peix, P. Newell et al., Focal gains of VEGFA and molecular classification of hepatocellular carcinoma, Cancer Res, vol.68, issue.16, pp.6779-6788, 2008.

H. Zhang, M. Yao, W. Wu, L. Qiu, W. Sai et al., Up-regulation of annexin