R. Stupp, W. Mason, and M. Van-den-bent, Radiotherapy plus Concomitant and Adjuvant Temozolomide for Glioblastoma, New England Journal of Medicine, vol.352, issue.10, pp.987-996, 2005.
DOI : 10.1056/NEJMoa043330

S. Tanaka, D. Louis, W. Curry, T. Batchelor, and J. Dietrich, Diagnostic and therapeutic avenues for glioblastoma: no longer a dead end?, Nature Reviews Clinical Oncology, vol.455, issue.1, pp.14-26, 2013.
DOI : 10.1038/nature07385

J. Chen and T. Xu, Recent therapeutic advances and insights of recurrent glioblastoma multiforme??, Frontiers in Bioscience, vol.18, issue.2
DOI : 10.2741/4130

, Front Biosci (Landmark Ed), vol.18, pp.676-684, 2013.

J. Hainsworth, T. Ervin, and E. Friedman, Concurrent radiotherapy and temozolomide followed by temozolomide and sorafenib in the first-line treatment of patients with glioblastoma multiforme, Cancer, vol.27, issue.15, pp.3663-3669, 2010.
DOI : 10.1038/bjc.1991.396

R. Den, M. Kamrava, and Z. Sheng, A Phase I Study of the Combination of Sorafenib With Temozolomide and Radiation Therapy for the Treatment of Primary and Recurrent High-Grade Gliomas, International Journal of Radiation Oncology*Biology*Physics, vol.85, issue.2, pp.321-328, 2013.
DOI : 10.1016/j.ijrobp.2012.04.017

R. Jain, Normalization of Tumor Vasculature: An Emerging Concept in Antiangiogenic Therapy, Science, vol.307, issue.5706, pp.58-62, 2005.
DOI : 10.1126/science.1104819

F. Winkler, S. Kozin, and R. Tong, Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation, Cancer Cell, vol.6, issue.6, pp.553-563, 2004.
DOI : 10.1016/j.ccr.2004.10.011

E. Barbier, L. Lamalle, and M. Décorps, Methodology of brain perfusion imaging, Journal of Magnetic Resonance Imaging, vol.11, issue.Suppl 5, pp.496-520, 2001.
DOI : 10.1038/jcbfm.1991.121

I. Troprès, S. Grimault, and A. Vaeth, Vessel size imaging, Magnetic Resonance in Medicine, vol.29, issue.3, pp.397-408, 2001.
DOI : 10.1002/1522-2594(200103)45:3<397::AID-MRM1052>3.0.CO;2-3

X. He and D. Yablonskiy, Quantitative BOLD: Mapping of human cerebral deoxygenated blood volume and oxygen extraction fraction: Default state, Magnetic Resonance in Medicine, vol.48, issue.1, pp.115-126, 2007.
DOI : 10.1148/radiology.201.1.8816529

P. Tofts, G. Brix, and D. Buckley, Estimating kinetic parameters from dynamic contrastenhanced t1-weighted MRI of a diffusable tracer: Standardized quantities and symbols, p.22

, Magnetic Resonance Imaging, vol.10, issue.3, pp.223-232, 1999.

A. Krainik, M. Hund-georgiadis, S. Zysset, D. Cramon, and . Von,

A. Bouchet and C. Maisin, Multiparametric MRI as an early biomarker of individual therapy effects during concomitant treatment of brain tumours, Cerebrovascular Reactivity and BOLD Signal in Adults After Stroke, pp.1146-11521163, 2005.
URL : https://hal.archives-ouvertes.fr/hal-01236292

S. Ken, A. Deviers, and T. Filleron, Voxel-based evidence of perfusion normalization in glioblastoma patients included in a phase I???II trial of radiotherapy/tipifarnib combination, Journal of Neuro-Oncology, vol.106, issue.3, pp.465-473, 2015.
DOI : 10.1038/bjc.2011.579

C. Fraley and A. Raftery, Model-Based Clustering, Discriminant Analysis, and Density Estimation, Journal of the American Statistical Association, vol.97, issue.458
DOI : 10.1198/016214502760047131

, Journal of the American Statistical Association, vol.97, issue.458, pp.611-631, 2002.

N. Coquery, O. Francois, and B. Lemasson, Microvascular MRI and Unsupervised Clustering Yields Histology-Resembling Images in Two Rat Models of Glioma, Journal of Cerebral Blood Flow & Metabolism, vol.24, issue.8, pp.1354-1362, 2014.
DOI : 10.1002/nbm.1263
URL : https://hal.archives-ouvertes.fr/hal-01119666

C. Kilkenny, W. Browne, I. Cuthill, M. Emerson, and D. Altman, Improving Bioscience Research

. Reporting, A. The, N. Guidelines-for-reporting-animal-research-coquery, N. Pannetier, and R. Farion, Distribution and Radiosensitizing Effect of Cholesterol-Coupled Dbait Molecule in Rat Model of Glioblastoma Interpulse phase corrections for unbalanced pseudo-continuous arterial spin labeling at high magnetic field, PLOS Biology. PLoS ONE. Magn Reson Med, vol.8779, issue.1873, pp.1314-1324, 2010.

I. Troprès, L. Lamalle, and M. Péoc-'h, In vivo assessment of tumoral angiogenesis, Magnetic Resonance in Medicine, vol.88, issue.Suppl, pp.533-541, 2004.
DOI : 10.1038/sj.bjc.6600837

B. Lemasson, R. Serduc, and C. Maisin, Monitoring Blood-Brain Barrier Status in a Rat Model of Glioma Receiving Therapy: Dual Injection of Low-Molecular-Weight and Macromolecular MR Contrast Media, Radiology, vol.257, issue.2, pp.342-352, 2010.
DOI : 10.1148/radiol.10092343
URL : https://hal.archives-ouvertes.fr/inserm-00589222

D. Alsop and J. Detre, Reduced Transit-Time Sensitivity in Noninvasive Magnetic Resonance Imaging of Human Cerebral Blood Flow, Journal of Cerebral Blood Flow & Metabolism, vol.99, issue.6, pp.1236-1249, 1996.
DOI : 10.1002/mrm.1910250216

R. Buxton, L. Frank, E. Wong, B. Siewert, S. Warach et al., A general kinetic model for quantitative perfusion imaging with arterial spin labeling Evaluation of a quantitative blood oxygenation level-dependent (qBOLD) approach to map local blood oxygen saturation, Magn Reson Med. NMR in Biomedicine, vol.4024, issue.244, pp.383-396393, 1998.

B. Lemasson, T. Christen, and X. Tizon, Assessment of multiparametric MRI in a human glioma model to monitor cytotoxic and anti-angiogenic drug effects, NMR in Biomedicine, vol.57, issue.(6 Suppl 16), pp.473-482, 2011.
DOI : 10.1002/mrm.21108
URL : https://hal.archives-ouvertes.fr/inserm-00607949

B. Lemasson, T. Christen, and R. Serduc, Evaluation of the Relationship between MR Estimates of Blood Oxygen Saturation and Hypoxia: Effect of an Antiangiogenic Treatment on a Gliosarcoma Model, Radiology, vol.265, issue.3, pp.743-752, 2012.
DOI : 10.1148/radiol.12112621

S. Valable, B. Lemasson, and R. Farion, Assessment of blood volume, vessel size, and the expression of angiogenic factors in two rat glioma models: a longitudinal in vivo and ex vivo study
URL : https://hal.archives-ouvertes.fr/inserm-00381408

, NMR Biomed, vol.21, issue.10, pp.1043-1056, 2008.

B. Lemasson, S. Valable, R. Farion, A. Krainik, C. Rémy et al., In vivo imaging of vessel diameter, size, and density: A comparative study between MRI and histology, Magnetic Resonance in Medicine, vol.25, issue.6 Suppl 16, pp.18-26, 2013.
DOI : 10.1002/nbm.1734
URL : https://hal.archives-ouvertes.fr/inserm-00861168

S. Cha, Neuroimaging in neuro-oncology, Neurotherapeutics, vol.243, issue.Suppl 1, pp.465-477, 2009.
DOI : 10.1148/radiol.2432060493

C. Galbán, T. Chenevert, and C. Meyer, The parametric response map is an imaging biomarker for early cancer treatment outcome, Nature Medicine, vol.1, issue.5, pp.572-576, 2009.
DOI : 10.1016/j.ijrobp.2005.09.001

D. Hamstra, T. Chenevert, and B. Moffat, Evaluation of the functional diffusion map as an early biomarker of time-to-progression and overall survival in high-grade glioma, Proceedings of the National Academy of Sciences, vol.22, issue.4, pp.16759-16764, 2005.
DOI : 10.1593/neo.03343

H. Aronen, I. Gazit, and D. Louis, Cerebral blood volume maps of gliomas: comparison with tumor grade and histologic findings Glioma grading by using histogram analysis of blood volume heterogeneity from MR-derived cerebral blood volume maps, Radiology. Radiology, vol.191247, issue.13, pp.41-51808, 1994.

C. Chung, S. Jalali, and W. Foltz, Imaging Biomarker Dynamics in an Intracranial Murine Glioma Study of Radiation and Antiangiogenic Therapy, International Journal of Radiation Oncology*Biology*Physics, vol.85, issue.3, pp.805-812, 2013.
DOI : 10.1016/j.ijrobp.2012.07.005

D. Hamstra, A. Rehemtulla, and B. Ross, Diffusion Magnetic Resonance Imaging: A Biomarker for Treatment Response in Oncology, Journal of Clinical Oncology, vol.25, issue.26, pp.4104-4109, 2007.
DOI : 10.1200/JCO.2007.11.9610

S. Goel, D. Duda, and L. Xu, Normalization of the Vasculature for Treatment of Cancer and Other Diseases, Physiological Reviews, vol.57, issue.3, pp.1071-1121, 2011.
DOI : 10.1200/JCO.2008.20.9908