Skip to Main content Skip to Navigation
Journal articles

Molecular and tissue alterations of collagens in fibrosis

Abstract : The collagen network is altered in fibrotic diseases associated with extracellular matrix (ECM) biosynthesis and remodeling. This mini-review focuses on the quantitative and qualitative modifications of collagens occurring at the molecular and tissue levels in fibrosis. They result from changes in collagen expression, biosynthesis, enzymatic cross-linking and degradation by several protease families. These molecular modifications, which are mostly regulated by TGF-β, are associated with altered collagen organization at the tissue level, leading to a fibrotic signature that can be analyzed by Second Harmonic Generation (SHG) microscopy.
Document type :
Journal articles
Complete list of metadata

Cited literature [360 references]  Display  Hide  Download
Contributor : Laurent Jonchère Connect in order to contact the contributor
Submitted on : Friday, April 12, 2019 - 1:15:50 PM
Last modification on : Wednesday, October 20, 2021 - 3:19:22 AM


Ricard-Blum et al_Molecular an...
Files produced by the author(s)



Sylvie Ricard-Blum, Georges Baffet, Nathalie Théret. Molecular and tissue alterations of collagens in fibrosis. Matrix Biology, Elsevier, 2018, 68-69, pp.122-149. ⟨10.1016/j.matbio.2018.02.004⟩. ⟨hal-01808771⟩



Record views


Files downloads